The behavioral pathology in Alzheimer's disease scale (Behave-AD): Factor structure among community-dwelling Alzheimer's disease patients

Dylan G. Harwood, Raymond L. Ownby, Warren W. Barker, Ranjan Duara

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Objective. The aims of this study were to (a) determine the factor structure of the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), and (b) examine the associations of the observed factors to the level of cognitive impairment. Design. Cross-sectional study of geriatric patients evaluated at an outpatient memory disorders clinic. Sample. One hundred and fifty-one consecutive patients diagnosed with Alzheimer's disease (AD) according to NINCDS-ADRDA diagnostic criteria. Results. Principal factors analysis with Varimax rotation resulted in a five-factor solution that accounted for 40.0% of the common variance. The factors included agitation/anxiety (agitation, anxiety of upcoming events; other anxiety), psychosis (delusions of theft, suspiciousness/paranoia; visual hallucinations), aggression (verbal aggressiveness, physical threats/violence; fear of being left alone; other delusions), depression (tearfulness; depressed mood) and activity disturbance (wandering; delusion one's house is not one's home). Several factors were associated with level of cognitive impairment as assessed by the Mini-Mental State Examination (MMSE). Conclusion. The results of this study suggest that the BEHAVE-AD measures a wide range of behavioral pathology that can be empirically represented by five independent symptom clusters among outpatient AD patients.

Original languageEnglish (US)
Pages (from-to)793-800
Number of pages8
JournalInternational Journal of Geriatric Psychiatry
Volume13
Issue number11
DOIs
StatePublished - Nov 1 1998

Keywords

  • Alzheimer's disease
  • Behavioral pathology
  • Factor analysis

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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