TY - JOUR
T1 - The behavioral pathology in Alzheimer's disease scale (Behave-AD)
T2 - Factor structure among community-dwelling Alzheimer's disease patients
AU - Harwood, Dylan G.
AU - Ownby, Raymond L.
AU - Barker, Warren W.
AU - Duara, Ranjan
PY - 1998/11/1
Y1 - 1998/11/1
N2 - Objective. The aims of this study were to (a) determine the factor structure of the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), and (b) examine the associations of the observed factors to the level of cognitive impairment. Design. Cross-sectional study of geriatric patients evaluated at an outpatient memory disorders clinic. Sample. One hundred and fifty-one consecutive patients diagnosed with Alzheimer's disease (AD) according to NINCDS-ADRDA diagnostic criteria. Results. Principal factors analysis with Varimax rotation resulted in a five-factor solution that accounted for 40.0% of the common variance. The factors included agitation/anxiety (agitation, anxiety of upcoming events; other anxiety), psychosis (delusions of theft, suspiciousness/paranoia; visual hallucinations), aggression (verbal aggressiveness, physical threats/violence; fear of being left alone; other delusions), depression (tearfulness; depressed mood) and activity disturbance (wandering; delusion one's house is not one's home). Several factors were associated with level of cognitive impairment as assessed by the Mini-Mental State Examination (MMSE). Conclusion. The results of this study suggest that the BEHAVE-AD measures a wide range of behavioral pathology that can be empirically represented by five independent symptom clusters among outpatient AD patients.
AB - Objective. The aims of this study were to (a) determine the factor structure of the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), and (b) examine the associations of the observed factors to the level of cognitive impairment. Design. Cross-sectional study of geriatric patients evaluated at an outpatient memory disorders clinic. Sample. One hundred and fifty-one consecutive patients diagnosed with Alzheimer's disease (AD) according to NINCDS-ADRDA diagnostic criteria. Results. Principal factors analysis with Varimax rotation resulted in a five-factor solution that accounted for 40.0% of the common variance. The factors included agitation/anxiety (agitation, anxiety of upcoming events; other anxiety), psychosis (delusions of theft, suspiciousness/paranoia; visual hallucinations), aggression (verbal aggressiveness, physical threats/violence; fear of being left alone; other delusions), depression (tearfulness; depressed mood) and activity disturbance (wandering; delusion one's house is not one's home). Several factors were associated with level of cognitive impairment as assessed by the Mini-Mental State Examination (MMSE). Conclusion. The results of this study suggest that the BEHAVE-AD measures a wide range of behavioral pathology that can be empirically represented by five independent symptom clusters among outpatient AD patients.
KW - Alzheimer's disease
KW - Behavioral pathology
KW - Factor analysis
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U2 - 10.1002/(SICI)1099-1166(1998110)13:11<793::AID-GPS875>3.0.CO;2-Q
DO - 10.1002/(SICI)1099-1166(1998110)13:11<793::AID-GPS875>3.0.CO;2-Q
M3 - Article
C2 - 9850876
AN - SCOPUS:0031770610
VL - 13
SP - 793
EP - 800
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 11
ER -