The balance between feeling and knowing: Affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics

Christine L. Cox, Lucina Q Uddin, Adriana Di martino, F. Xavier Castellanos, Michael P. Milham, Clare Kelly

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Affective empathy (AE) is distinguished clinically and neurally from cognitive empathy (CE). While AE is selectively disrupted in psychopathy, autism is associated with deficits in CE. Despite such dissociations, AE and CE together contribute to normal human empathic experience. A dimensional measure of individual differences in AE 'relative to' CE captures this interaction and may reveal brain-behavior relationships beyond those detectable with AE and CE separately. Using resting-state fMRI and measures of empathy in healthy adults, we show that relative empathic ability (REA) is reflected in the brain's intrinsic functional dynamics. Dominance of AE was associated with stronger functional connectivity among social-emotional regions (ventral anterior insula, orbitofrontal cortex, amygdala, perigenual anterior cingulate). Dominance of CE was related to stronger connectivity among areas implicated in interoception, autonomic monitoring and social-cognitive processing (brainstem, superior temporal sulcus, ventral anterior insula). These patterns were distinct from those observed with AE and CE separately. Finally, REA and the strength of several functional connections were associated with symptoms of psychopathology. These findings suggest that REA provides a dimensional index of empathic function and pathological tendencies in healthy adults, which are reflected in the intrinsic functional dynamics of neural systems associated with social and emotional cognition.

Original languageEnglish (US)
Article numbernsr051
Pages (from-to)727-737
Number of pages11
JournalSocial Cognitive and Affective Neuroscience
Volume7
Issue number6
DOIs
StatePublished - Aug 2012
Externally publishedYes

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Emotions
Brain
Aptitude
Dissociative Disorders
Gyrus Cinguli
Temporal Lobe
Autistic Disorder
Amygdala
Prefrontal Cortex
Psychopathology
Individuality
Cognition
Brain Stem
Magnetic Resonance Imaging

Keywords

  • Affective empathy
  • Cognitive empathy
  • FMRI
  • Resting-state functional connectivity
  • Social cognition

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

The balance between feeling and knowing : Affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics. / Cox, Christine L.; Uddin, Lucina Q; Di martino, Adriana; Castellanos, F. Xavier; Milham, Michael P.; Kelly, Clare.

In: Social Cognitive and Affective Neuroscience, Vol. 7, No. 6, nsr051, 08.2012, p. 727-737.

Research output: Contribution to journalArticle

Cox, Christine L. ; Uddin, Lucina Q ; Di martino, Adriana ; Castellanos, F. Xavier ; Milham, Michael P. ; Kelly, Clare. / The balance between feeling and knowing : Affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics. In: Social Cognitive and Affective Neuroscience. 2012 ; Vol. 7, No. 6. pp. 727-737.
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