The Autism Sequencing Consortium: Large-Scale, High-Throughput Sequencing in Autism Spectrum Disorders

The Autism Sequencing Consortium

Research output: Contribution to journalShort survey

97 Scopus citations

Abstract

Research during the past decade has seen significant progress in the understanding of the genetic architecture of autism spectrum disorders (ASDs), with gene discovery accelerating as the characterization of genomic variation has become increasingly comprehensive. At the same time, this research has highlighted ongoing challenges. Here we address the enormous impact of high-throughput sequencing (HTS) on ASD gene discovery, outline a consensus view for leveraging this technology, and describe a large multisite collaboration developed to accomplish these goals. Similar approaches could prove effective for severe neurodevelopmental disorders more broadly.

Original languageEnglish (US)
Pages (from-to)1052-1056
Number of pages5
JournalNeuron
Volume76
Issue number6
DOIs
StatePublished - Dec 20 2012

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ASJC Scopus subject areas

  • Neuroscience(all)

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