The astroglial response to Wallerian degeneration after spinal cord injury in humans

W. R. Puckett, E. D. Hiester, Michael D Norenberg, Alexander Marcillo, R. P. Bunge

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We describe the changes exhibited by astrocytes in areas of Wallerian degeneration after spinal cord injury in humans using glial fibrillary acidic protein immunohistochemistry correlated to standard histology at time points ranging from 8 days to 23 years after injury. Astrocytes were slow to react; a slight increase in immunoreactivity was observed at 4 months. Over time they began to lose immunoreactivity in both the somata and the processes as the debris from the degenerative process was cleared. By 1 year after injury the staining intensity had decreased to levels which were lower than in normal areas of the cord. This hypointense staining persisted for at least 23 years after injury. These findings are significantly different from those observed in animal studies and emphasize the need for additional pathological studies of human spinal cord injury.

Original languageEnglish
Pages (from-to)424-432
Number of pages9
JournalExperimental Neurology
Volume148
Issue number2
DOIs
StatePublished - Dec 1 1997

Fingerprint

Wallerian Degeneration
Spinal Cord Injuries
Astrocytes
Wounds and Injuries
Staining and Labeling
Glial Fibrillary Acidic Protein
Carisoprodol
Histology
Immunohistochemistry

Keywords

  • Astrocytes
  • GFAP
  • Human spinal cord injury
  • Wallerian degeneration

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

The astroglial response to Wallerian degeneration after spinal cord injury in humans. / Puckett, W. R.; Hiester, E. D.; Norenberg, Michael D; Marcillo, Alexander; Bunge, R. P.

In: Experimental Neurology, Vol. 148, No. 2, 01.12.1997, p. 424-432.

Research output: Contribution to journalArticle

Puckett, W. R. ; Hiester, E. D. ; Norenberg, Michael D ; Marcillo, Alexander ; Bunge, R. P. / The astroglial response to Wallerian degeneration after spinal cord injury in humans. In: Experimental Neurology. 1997 ; Vol. 148, No. 2. pp. 424-432.
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