The Association of Age with Short-Term and Long-Term Mortality in Adults Admitted to the Intensive Care Unit

Raghu R. Seethala, Kevin Blackney, Peter Hou, Haytham M.A. Kaafarani, Daniel Dante Yeh, Imoigele Aisiku, Christopher Tainter, Marc Demoya, David King, Jarone Lee

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Based on the current literature, it is unclear whether advanced age itself leads to higher mortality in critically ill patients or whether it is due to the greater number of comorbidities in the elderly patients. We hypothesized that increasing age would increase the odds of short-term and long-term mortality after adjusting for baseline comorbidities in intensive care unit (ICU) patients. Methods: We performed a retrospective cohort study of 57 160 adults admitted to any ICU over 5 years at 2 academic tertiary care centers. Patients were divided into age-groups, 18 to 39, 40 to 59, 60 to 79, and ≥80. The primary outcomes were 30-day and 365-day mortality. Results were analyzed with multivariate logistic regression adjusting for demographics and the Elixhauser-van Walraven Comorbidity Index. Results: The adjusted 30-day mortality odds ratios (ORs) were 1.39 (95% confidence interval [CI]: 1.21-1.60), 2.00 (95% CI: 1.75-2.28), and 3.33 (95% CI: 2.90-3.82) for age-groups 40 to 59, 60 to 79, and ≥80, respectively, using the age-group 18 to 39 as the reference. The adjusted 365-day mortality ORs were 1.46 (95% CI: 1.32-1.61), 2.10 (95% CI: 1.91-2.31), and 2.96 (95% CI: 2.67-3.27). Conclusion: In critically ill patients, increasing age is associated with higher odds of short-term and long-term death after correcting for existing comorbidities.

Original languageEnglish (US)
Pages (from-to)554-558
Number of pages5
JournalJournal of Intensive Care Medicine
Issue number9
StatePublished - Oct 1 2017
Externally publishedYes


  • age
  • comorbidity index
  • elderly
  • intensive care unit
  • mortality

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'The Association of Age with Short-Term and Long-Term Mortality in Adults Admitted to the Intensive Care Unit'. Together they form a unique fingerprint.

Cite this