The Association of Affective Disorder with Huntington's Disease in a Case Series and in Families

Susan E. Folstein, Gary A. Chase, Barbara A. Jensen, Marshal F. Folstein

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

Major affective disorder clinically similar to the disorder found in conditions other than Huntington's Disease (HD) was found in 41% of patients with HD in a consecutive case series ascertained through multiple sources in a defined geographical area. The association appears to be confined to certain families, and affective disorder may appear as long as 20 years before the onset of chorea and dementia. The association may represent genetic heterogeneity in HD.

Original languageEnglish (US)
Pages (from-to)537-542
Number of pages6
JournalPsychological medicine
Volume13
Issue number3
DOIs
StatePublished - Aug 1983

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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