The association between sleep characteristics and prothrombotic markers in a population-based sample

Chicago Area Sleep Study

Zehra Tosur, David Green, Peter John De Chavez, Kristen L. Knutson, Jeffrey Goldberger, Phyllis Zee, Kiang Liu, Kwang Youn Kim, Mercedes R. Carnethon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and aim: Short sleep duration and poor quality sleep are associated with coronary heart disease (CHD) mortality; however, the underlying pathophysiologic process remains unclear. Sleep apnea may confound the association because of its relationship with formation of thrombi, the vascular occlusive process in CHD. We tested whether sleep duration and quality were associated with prothrombotic biomarkers in adults with a low probability of apnea. Methods: We included adults aged 35-64. years recruited from the community and who had an apnea hypopnea index <15 after one night of screening (n=506). Sleep duration and maintenance were determined from 7. days of wrist actigraphy; daytime sleepiness was estimated using the Epworth Sleepiness Scale. Factor VIII (FVIII), von Willebrand factor (vWF), thrombin antithrombin (TAT) complexes, and plasminogen activator inhibitor-1 (PAI-1) were measured in fasting blood. Results: Sleep duration, maintenance, and daytime sleepiness were not associated with FVIII, vWf, or TAT. Sleep maintenance was modestly inversely associated with higher levels of log-transformed PAI-1 (β=-0.07, standard error (SE)=0.03 per 4.8%, p=0.04) following adjustment for demographic characteristics, cardiovascular risk factors, and body mass index (BMI). Conclusions: Mild impairment in sleep was modestly associated with activation of coagulation; further study is needed to evaluate the role of fibrinolytic factors in sleep-mediated coronary thrombosis.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalSleep Medicine
Volume15
Issue number8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Sleep
Population
Plasminogen Activator Inhibitor 1
Maintenance
Apnea
Coronary Disease
Actigraphy
Coronary Thrombosis
Antithrombins
Sleep Apnea Syndromes
Factor VIII
Wrist
Thrombin
Blood Vessels
Fasting
Body Mass Index
Thrombosis
Biomarkers
Demography
Mortality

Keywords

  • Cardiovascular disease
  • Hemostatic factors
  • Population studies
  • Procoagulants
  • Sleep apnea
  • Sleep duration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The association between sleep characteristics and prothrombotic markers in a population-based sample : Chicago Area Sleep Study. / Tosur, Zehra; Green, David; De Chavez, Peter John; Knutson, Kristen L.; Goldberger, Jeffrey; Zee, Phyllis; Liu, Kiang; Kim, Kwang Youn; Carnethon, Mercedes R.

In: Sleep Medicine, Vol. 15, No. 8, 01.01.2014, p. 973-978.

Research output: Contribution to journalArticle

Tosur, Zehra ; Green, David ; De Chavez, Peter John ; Knutson, Kristen L. ; Goldberger, Jeffrey ; Zee, Phyllis ; Liu, Kiang ; Kim, Kwang Youn ; Carnethon, Mercedes R. / The association between sleep characteristics and prothrombotic markers in a population-based sample : Chicago Area Sleep Study. In: Sleep Medicine. 2014 ; Vol. 15, No. 8. pp. 973-978.
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