The association between kidney disease and cardiovascular risk in a multiethnic cohort: Findings from the Northern Manhattan Study (NOMAS)

Thomas L. Nickolas, Minesh Khatri, Bernadette Boden-Albala, Krzysztof Kiryluk, Xiaodong Luo, Palma Gervasi-Franklin, Myunghee Paik, Ralph L. Sacco

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Background and Purpose: The objective of this study was to determine the relationship between chronic kidney disease (CKD), race-ethnicity, and vascular outcomes. Methods: A prospective, multiracial cohort of 3298 stroke-free subjects with 6.5 years of mean follow-up time for vascular outcomes (stroke, myocardial infarction, vascular death) was used. Kidney function was estimated using serum creatinine and Cockcroft-Gault formula. Cox proportional hazards models were fitted to evaluate the relationship between kidney function and vascular outcomes. Results: In multivariate analysis, Cockcroft-Gault formula between 15 and 59 mL/min was associated with a significant 43% increased stroke risk in the overall cohort. Blacks with Cockcroft-Gault formula between 15 and 59 mL/min had significantly increased risk of both stroke (hazard ratio, 2.65; 95% CI, 1.47 to 4.77) and combined vascular outcomes (hazard ratio, 1.59; 95% CI, 1.10-2.92). Conclusion: Chronic kidney disease is a significant risk factor for stroke and combined vascular events, especially in blacks.

Original languageEnglish (US)
Pages (from-to)2876-2879
Number of pages4
JournalStroke
Volume39
Issue number10
DOIs
StatePublished - Oct 1 2008

Keywords

  • Cardiac
  • Chronic kidney disease
  • Epidemiology
  • Outcome
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Medicine(all)

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