The association between a mediterranean-style diet and kidney function in the northern manhattan study cohort

Minesh Khatri, Yeseon P. Moon, Nikolaos Scarmeas, Yian Gu, Hannah Gardener, Ken Cheung, Clinton B Wright, Ralph L Sacco, Thomas L. Nickolas, Mitchell S V Elkind

Research output: Contribution to journalArticle

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Abstract

Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknownwhether aMediterranean diet,which has been associatedwith improved cardiovascular risk, is associated with change in kidney function Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnairewas extrapolated into a previously used 9-point scoring system(MeDi). The primary outcomewas incident eGFR,60 ml/min per 1.73 m2using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline (≥2.5 ml/min per 1.73 m2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors. Results Mean baseline age was 64 years, with 59% women and 65% Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m2. Incident eGFR,60 ml/min per 1.73 m2 developed in 14%. In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR,60 ml/min per 1.73 m2 (odds ratio, 0.83; 95% confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95% confidence interval, 0.79 to 0.98). Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR,60 ml/min per 1.73m2 and upper quartile of eGFR decline in a multiethnic cohort.

Original languageEnglish
Pages (from-to)1868-1875
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume9
Issue number11
DOIs
StatePublished - 2014

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Mediterranean Diet
Cohort Studies
Kidney
Logistic Models
Odds Ratio
Confidence Intervals
Diet Therapy
Hispanic Americans
Creatinine
Stroke
Demography
Prospective Studies
Diet
Incidence
Serum

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

The association between a mediterranean-style diet and kidney function in the northern manhattan study cohort. / Khatri, Minesh; Moon, Yeseon P.; Scarmeas, Nikolaos; Gu, Yian; Gardener, Hannah; Cheung, Ken; Wright, Clinton B; Sacco, Ralph L; Nickolas, Thomas L.; Elkind, Mitchell S V.

In: Clinical Journal of the American Society of Nephrology, Vol. 9, No. 11, 2014, p. 1868-1875.

Research output: Contribution to journalArticle

Khatri, M, Moon, YP, Scarmeas, N, Gu, Y, Gardener, H, Cheung, K, Wright, CB, Sacco, RL, Nickolas, TL & Elkind, MSV 2014, 'The association between a mediterranean-style diet and kidney function in the northern manhattan study cohort', Clinical Journal of the American Society of Nephrology, vol. 9, no. 11, pp. 1868-1875. https://doi.org/10.2215/CJN.01080114
Khatri, Minesh ; Moon, Yeseon P. ; Scarmeas, Nikolaos ; Gu, Yian ; Gardener, Hannah ; Cheung, Ken ; Wright, Clinton B ; Sacco, Ralph L ; Nickolas, Thomas L. ; Elkind, Mitchell S V. / The association between a mediterranean-style diet and kidney function in the northern manhattan study cohort. In: Clinical Journal of the American Society of Nephrology. 2014 ; Vol. 9, No. 11. pp. 1868-1875.
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abstract = "Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknownwhether aMediterranean diet,which has been associatedwith improved cardiovascular risk, is associated with change in kidney function Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnairewas extrapolated into a previously used 9-point scoring system(MeDi). The primary outcomewas incident eGFR,60 ml/min per 1.73 m2using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline (≥2.5 ml/min per 1.73 m2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors. Results Mean baseline age was 64 years, with 59{\%} women and 65{\%} Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m2. Incident eGFR,60 ml/min per 1.73 m2 developed in 14{\%}. In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR,60 ml/min per 1.73 m2 (odds ratio, 0.83; 95{\%} confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95{\%} confidence interval, 0.79 to 0.98). Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR,60 ml/min per 1.73m2 and upper quartile of eGFR decline in a multiethnic cohort.",
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AU - Khatri, Minesh

AU - Moon, Yeseon P.

AU - Scarmeas, Nikolaos

AU - Gu, Yian

AU - Gardener, Hannah

AU - Cheung, Ken

AU - Wright, Clinton B

AU - Sacco, Ralph L

AU - Nickolas, Thomas L.

AU - Elkind, Mitchell S V

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N2 - Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknownwhether aMediterranean diet,which has been associatedwith improved cardiovascular risk, is associated with change in kidney function Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnairewas extrapolated into a previously used 9-point scoring system(MeDi). The primary outcomewas incident eGFR,60 ml/min per 1.73 m2using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline (≥2.5 ml/min per 1.73 m2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors. Results Mean baseline age was 64 years, with 59% women and 65% Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m2. Incident eGFR,60 ml/min per 1.73 m2 developed in 14%. In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR,60 ml/min per 1.73 m2 (odds ratio, 0.83; 95% confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95% confidence interval, 0.79 to 0.98). Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR,60 ml/min per 1.73m2 and upper quartile of eGFR decline in a multiethnic cohort.

AB - Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknownwhether aMediterranean diet,which has been associatedwith improved cardiovascular risk, is associated with change in kidney function Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnairewas extrapolated into a previously used 9-point scoring system(MeDi). The primary outcomewas incident eGFR,60 ml/min per 1.73 m2using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline (≥2.5 ml/min per 1.73 m2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors. Results Mean baseline age was 64 years, with 59% women and 65% Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m2. Incident eGFR,60 ml/min per 1.73 m2 developed in 14%. In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR,60 ml/min per 1.73 m2 (odds ratio, 0.83; 95% confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95% confidence interval, 0.79 to 0.98). Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR,60 ml/min per 1.73m2 and upper quartile of eGFR decline in a multiethnic cohort.

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