Abstract
Purpose Diabetic retinopathy (DR) is a microvascular disease characterized by capillary dropout and resultant retinal ischemia which then leads to retinal vascular remodeling. Our goal was to assess blood flow velocities in retinal collateral vessels in healthy and diabetic subjects with various stages of DR. Methods In our pilot study, we enrolled five eyes of five healthy subjects (H), five eyes of four subjects with diabetes and no retinopathy (DM), three eyes of three subjects with mild non-proliferative diabetic retinopathy (MDR), and five eyes of four subjects with proliferative diabetic retinopathy (PDR). Following routine ophthalmic examination, all subjects were imaged using a retinal function imager (RFI; Optical Imaging Inc., Rehovot, Israel). The built-in software of the RFI was used to identify and segment retinal collaterals with measurement of the blood flow velocities (BFV). One-way ANOVA was performed for BFV, followed by Newman-Keuls post hoc test. The level of significance was set at 5%. Results The total number of collateral segments involved in the study was 30, 31, 21, and 39 in the H, DM, MDR, and PDR groups, respectively. The BFVs in the collaterals were significantly lower in PDR (H: 1.86 ± 0.67, DM: 1.91 ± 0.71, MDR: 1.71 ± 0.53, PDR: 1.37 ± 0.58 mm/s). The PDR group showed a statistically significant difference in the comparisons to all groups (p = 0.012, p = 0.008, and p = 0.043 for the H, DM, and MDR groups, respectively), while no other comparisons between the groups were significant. Conclusion We observed decreased BFV in retinal collaterals in PDR that may be due to the extensive capillary dropout and retinal ischemia. Further studies are needed for the noninvasive functional assessment of retinal microvascular changes in DR to better understand the underlying pathophysiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 530-535 |
| Number of pages | 6 |
| Journal | Klinische Monatsblatter fur Augenheilkunde |
| Volume | 236 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- blood flow
- collaterals
- diabetic retinopathy
- retina
- Retinal Function Imager
ASJC Scopus subject areas
- Ophthalmology
Cite this
The Assessment of Blood Flow Velocities in Retinal Collaterals in Diabetic Retinopathy. / Somfai, Gabor Mark; Campagnoli, Thalmon R.; Tian, Jing; Gerding, Heinrich; Smiddy, William E; Cabrera DeBuc, Delia.
In: Klinische Monatsblatter fur Augenheilkunde, Vol. 236, No. 4, 01.01.2019, p. 530-535.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The Assessment of Blood Flow Velocities in Retinal Collaterals in Diabetic Retinopathy
AU - Somfai, Gabor Mark
AU - Campagnoli, Thalmon R.
AU - Tian, Jing
AU - Gerding, Heinrich
AU - Smiddy, William E
AU - Cabrera DeBuc, Delia
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose Diabetic retinopathy (DR) is a microvascular disease characterized by capillary dropout and resultant retinal ischemia which then leads to retinal vascular remodeling. Our goal was to assess blood flow velocities in retinal collateral vessels in healthy and diabetic subjects with various stages of DR. Methods In our pilot study, we enrolled five eyes of five healthy subjects (H), five eyes of four subjects with diabetes and no retinopathy (DM), three eyes of three subjects with mild non-proliferative diabetic retinopathy (MDR), and five eyes of four subjects with proliferative diabetic retinopathy (PDR). Following routine ophthalmic examination, all subjects were imaged using a retinal function imager (RFI; Optical Imaging Inc., Rehovot, Israel). The built-in software of the RFI was used to identify and segment retinal collaterals with measurement of the blood flow velocities (BFV). One-way ANOVA was performed for BFV, followed by Newman-Keuls post hoc test. The level of significance was set at 5%. Results The total number of collateral segments involved in the study was 30, 31, 21, and 39 in the H, DM, MDR, and PDR groups, respectively. The BFVs in the collaterals were significantly lower in PDR (H: 1.86 ± 0.67, DM: 1.91 ± 0.71, MDR: 1.71 ± 0.53, PDR: 1.37 ± 0.58 mm/s). The PDR group showed a statistically significant difference in the comparisons to all groups (p = 0.012, p = 0.008, and p = 0.043 for the H, DM, and MDR groups, respectively), while no other comparisons between the groups were significant. Conclusion We observed decreased BFV in retinal collaterals in PDR that may be due to the extensive capillary dropout and retinal ischemia. Further studies are needed for the noninvasive functional assessment of retinal microvascular changes in DR to better understand the underlying pathophysiology.
AB - Purpose Diabetic retinopathy (DR) is a microvascular disease characterized by capillary dropout and resultant retinal ischemia which then leads to retinal vascular remodeling. Our goal was to assess blood flow velocities in retinal collateral vessels in healthy and diabetic subjects with various stages of DR. Methods In our pilot study, we enrolled five eyes of five healthy subjects (H), five eyes of four subjects with diabetes and no retinopathy (DM), three eyes of three subjects with mild non-proliferative diabetic retinopathy (MDR), and five eyes of four subjects with proliferative diabetic retinopathy (PDR). Following routine ophthalmic examination, all subjects were imaged using a retinal function imager (RFI; Optical Imaging Inc., Rehovot, Israel). The built-in software of the RFI was used to identify and segment retinal collaterals with measurement of the blood flow velocities (BFV). One-way ANOVA was performed for BFV, followed by Newman-Keuls post hoc test. The level of significance was set at 5%. Results The total number of collateral segments involved in the study was 30, 31, 21, and 39 in the H, DM, MDR, and PDR groups, respectively. The BFVs in the collaterals were significantly lower in PDR (H: 1.86 ± 0.67, DM: 1.91 ± 0.71, MDR: 1.71 ± 0.53, PDR: 1.37 ± 0.58 mm/s). The PDR group showed a statistically significant difference in the comparisons to all groups (p = 0.012, p = 0.008, and p = 0.043 for the H, DM, and MDR groups, respectively), while no other comparisons between the groups were significant. Conclusion We observed decreased BFV in retinal collaterals in PDR that may be due to the extensive capillary dropout and retinal ischemia. Further studies are needed for the noninvasive functional assessment of retinal microvascular changes in DR to better understand the underlying pathophysiology.
KW - blood flow
KW - collaterals
KW - diabetic retinopathy
KW - retina
KW - Retinal Function Imager
UR - http://www.scopus.com/inward/record.url?scp=85064979430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064979430&partnerID=8YFLogxK
U2 - 10.1055/a-0861-9675
DO - 10.1055/a-0861-9675
M3 - Article
C2 - 30999330
AN - SCOPUS:85064979430
VL - 236
SP - 530
EP - 535
JO - Klinische Monatsblatter fur Augenheilkunde
JF - Klinische Monatsblatter fur Augenheilkunde
SN - 0023-2165
IS - 4
ER -