The artificial pancreas: Current status and future prospects in the management of diabetes

Thomas Peyser, Eyal Dassau, Marc Breton, Jay S. Skyler

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Recent advances in insulins, insulin pumps, continuous glucose-monitoring systems, and control algorithms have resulted in an acceleration of progress in the development of artificial pancreas devices. This review discusses progress in the development of external systems that are based on subcutaneous drug delivery and subcutaneous continuous glucose monitoring. There are two major system-level approaches to achieving closed-loop control of blood glucose in diabetic individuals. The unihormonal approach uses insulin to reduce blood glucose and relies on complex safety mitigation algorithms to reduce the risk of hypoglycemia. The bihormonal approach uses both insulin to lower blood glucose and glucagon to raise blood glucose, and also relies on complex algorithms to provide for safety of the user. There are several major strategies for the design of control algorithms and supervision control for application to the artificial pancreas: proportional-integral-derivative, model predictive control, fuzzy logic, and safety supervision designs. Advances in artificial pancreas research in the first decade of this century were based on the ongoing computer revolution and miniaturization of electronic technology. The advent of modern smartphones has created the ability to utilize smartphone technology as the engineering centerpiece of an artificial pancreas. With these advances, an artificial or bionic pancreas is within reach.

Original languageEnglish (US)
Pages (from-to)102-123
Number of pages22
JournalAnnals of the New York Academy of Sciences
Volume1311
Issue number1
DOIs
StatePublished - Apr 2014

Keywords

  • Algorithms
  • Artificial pancreas
  • Continuous glucose monitoring
  • Insulin
  • Insulin infusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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