The arctic ground squirrel brain is resistant to injury from cardiac arrest during euthermia

Kunjan R Dave, Ricardo Prado, Ami Raval, Kelly L. Drew, Miguel Perez-Pinzon

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background and Purpose - Hetereothermic mammals tolerate hypoxia during euthermy and torpor, and evidence suggests this tolerance may extend beyond hypoxia to cerebral ischemia. During hibernation, CA1 hippocampal neurons endure extreme fluctuations in cerebral blood flow during transitions into and out of torpor as well as reductions in cerebral blood flow during torpor. In vitro studies likewise show evidence of ischemia tolerance in hippocampal slices harvested from euthermic ground squirrels; however, no studies have investigated tolerance in a clinically relevant model of in vivo global cerebral ischemia. The purpose of the present study was to test the hypothesis that the euthermic Arctic ground squirrel (AGS; Spermophillus parryii) is resistant to injury from asphyxial cardiac arrest (CA). Methods - Estrous-matched female rats were used as a positive control. Female euthermic AGS and rats were subjected to 8-minute CA. At the end of 7 days of reperfusion, AGS and rats were fixed for histopathological assessment. Results - In rats subjected to CA, the number of ischemic neurons was significantly higher (P<0.001) compared with control rats in hippocampus and striatum. Cortex was mildly injured. Surprisingly, neuronal counts in AGS were not significantly different in CA and control groups in these brain regions. Conclusion - These data demonstrate that AGS are remarkably tolerant to global cerebral ischemia during euthermia. A better understanding of the mechanisms by which AGS tolerate severe reductions in blood flow during euthermia may provide novel neuroprotective strategies that may translate into significant improvements in human patient outcomes after CA.

Original languageEnglish
Pages (from-to)1261-1265
Number of pages5
JournalStroke
Volume37
Issue number5
DOIs
StatePublished - May 1 2006

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Sciuridae
Heart Arrest
Torpor
Cerebrovascular Circulation
Wounds and Injuries
Brain
Brain Ischemia
Brain Hypoxia-Ischemia
Neurons
Hibernation
Reperfusion
Mammals
Hippocampus
Ischemia
Control Groups

Keywords

  • Cerebral ischemia
  • Heart arrest
  • Neuroprotection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

The arctic ground squirrel brain is resistant to injury from cardiac arrest during euthermia. / Dave, Kunjan R; Prado, Ricardo; Raval, Ami; Drew, Kelly L.; Perez-Pinzon, Miguel.

In: Stroke, Vol. 37, No. 5, 01.05.2006, p. 1261-1265.

Research output: Contribution to journalArticle

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