The architecture of the tau haplotype block in different ethnicities

Hon Chung Fung, Jessica Evans, Whitney Evans, Jaime Duckworth, Alan Pittman, Rohan De Silva, Amanda Myers, John Hardy

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume377
Issue number2
DOIs
StatePublished - Mar 29 2005
Externally publishedYes

Keywords

  • FTDP-17
  • Linkage disequilibrium
  • MAPT gene
  • Populations genetics
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

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    Fung, H. C., Evans, J., Evans, W., Duckworth, J., Pittman, A., De Silva, R., Myers, A., & Hardy, J. (2005). The architecture of the tau haplotype block in different ethnicities. Neuroscience Letters, 377(2), 81-84. https://doi.org/10.1016/j.neulet.2004.11.072