The architecture of the tau haplotype block in different ethnicities

Hon Chung Fung, Jessica Evans, Whitney Evans, Jaime Duckworth, Alan Pittman, Rohan De Silva, Amanda J Myers, John Hardy

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume377
Issue number2
DOIs
StatePublished - Mar 29 2005
Externally publishedYes

Fingerprint

Haplotypes
Linkage Disequilibrium
Ethnic Groups
Genes

Keywords

  • FTDP-17
  • Linkage disequilibrium
  • MAPT gene
  • Populations genetics
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fung, H. C., Evans, J., Evans, W., Duckworth, J., Pittman, A., De Silva, R., ... Hardy, J. (2005). The architecture of the tau haplotype block in different ethnicities. Neuroscience Letters, 377(2), 81-84. https://doi.org/10.1016/j.neulet.2004.11.072

The architecture of the tau haplotype block in different ethnicities. / Fung, Hon Chung; Evans, Jessica; Evans, Whitney; Duckworth, Jaime; Pittman, Alan; De Silva, Rohan; Myers, Amanda J; Hardy, John.

In: Neuroscience Letters, Vol. 377, No. 2, 29.03.2005, p. 81-84.

Research output: Contribution to journal › Article

Fung, HC, Evans, J, Evans, W, Duckworth, J, Pittman, A, De Silva, R, Myers, AJ & Hardy, J 2005, 'The architecture of the tau haplotype block in different ethnicities', Neuroscience Letters, vol. 377, no. 2, pp. 81-84. https://doi.org/10.1016/j.neulet.2004.11.072
Fung HC, Evans J, Evans W, Duckworth J, Pittman A, De Silva R et al. The architecture of the tau haplotype block in different ethnicities. Neuroscience Letters. 2005 Mar 29;377(2):81-84. https://doi.org/10.1016/j.neulet.2004.11.072
Fung, Hon Chung ; Evans, Jessica ; Evans, Whitney ; Duckworth, Jaime ; Pittman, Alan ; De Silva, Rohan ; Myers, Amanda J ; Hardy, John. / The architecture of the tau haplotype block in different ethnicities. In: Neuroscience Letters. 2005 ; Vol. 377, No. 2. pp. 81-84.
@article{01f16b2fa43d4be2878bf24ac5d4895c,
title = "The architecture of the tau haplotype block in different ethnicities",
abstract = "We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.",
keywords = "FTDP-17, Linkage disequilibrium, MAPT gene, Populations genetics, Progressive supranuclear palsy, Tau",
author = "Fung, {Hon Chung} and Jessica Evans and Whitney Evans and Jaime Duckworth and Alan Pittman and {De Silva}, Rohan and Myers, {Amanda J} and John Hardy",
year = "2005",
month = "3",
day = "29",
doi = "10.1016/j.neulet.2004.11.072",
language = "English",
volume = "377",
pages = "81--84",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - The architecture of the tau haplotype block in different ethnicities

AU - Fung, Hon Chung

AU - Evans, Jessica

AU - Evans, Whitney

AU - Duckworth, Jaime

AU - Pittman, Alan

AU - De Silva, Rohan

AU - Myers, Amanda J

AU - Hardy, John

PY - 2005/3/29

Y1 - 2005/3/29

N2 - We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

AB - We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

KW - FTDP-17

KW - Linkage disequilibrium

KW - MAPT gene

KW - Populations genetics

KW - Progressive supranuclear palsy

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=14644440480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14644440480&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.11.072

DO - 10.1016/j.neulet.2004.11.072

M3 - Article

C2 - 15740841

AN - SCOPUS:14644440480

VL - 377

SP - 81

EP - 84

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

Access to Document