The architecture of the tau haplotype block in different ethnicities

Hon Chung Fung; Jessica Evans; Whitney Evans; Jaime Duckworth; Alan Pittman; Rohan De Silva; Amanda Myers; John Hardy

doi:10.1016/j.neulet.2004.11.072

The architecture of the tau haplotype block in different ethnicities

Hon Chung Fung, Jessica Evans, Whitney Evans, Jaime Duckworth, Alan Pittman, Rohan De Silva, Amanda Myers, John Hardy

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

Original language	English (US)
Pages (from-to)	81-84
Number of pages	4
Journal	Neuroscience Letters
Volume	377
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2004.11.072
State	Published - Mar 29 2005
Externally published	Yes

Keywords

FTDP-17
Linkage disequilibrium
MAPT gene
Populations genetics
Progressive supranuclear palsy
Tau

ASJC Scopus subject areas

Neuroscience(all)

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AU - Evans, Jessica

AU - Evans, Whitney

AU - Duckworth, Jaime

AU - Pittman, Alan

AU - De Silva, Rohan

AU - Myers, Amanda

AU - Hardy, John

PY - 2005/3/29

Y1 - 2005/3/29

N2 - We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

AB - We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

KW - FTDP-17

KW - Linkage disequilibrium

KW - MAPT gene

KW - Populations genetics

KW - Progressive supranuclear palsy

KW - Tau

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JO - Neuroscience Letters

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The architecture of the tau haplotype block in different ethnicities

Abstract

Keywords

ASJC Scopus subject areas

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