The architecture of the tau haplotype block in different ethnicities

Hon Chung Fung, Jessica Evans, Whitney Evans, Jaime Duckworth, Alan Pittman, Rohan De Silva, Amanda J Myers, John Hardy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume377
Issue number2
DOIs
StatePublished - Mar 29 2005
Externally publishedYes

Fingerprint

Haplotypes
Linkage Disequilibrium
Ethnic Groups
Genes

Keywords

  • FTDP-17
  • Linkage disequilibrium
  • MAPT gene
  • Populations genetics
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fung, H. C., Evans, J., Evans, W., Duckworth, J., Pittman, A., De Silva, R., ... Hardy, J. (2005). The architecture of the tau haplotype block in different ethnicities. Neuroscience Letters, 377(2), 81-84. https://doi.org/10.1016/j.neulet.2004.11.072

The architecture of the tau haplotype block in different ethnicities. / Fung, Hon Chung; Evans, Jessica; Evans, Whitney; Duckworth, Jaime; Pittman, Alan; De Silva, Rohan; Myers, Amanda J; Hardy, John.

In: Neuroscience Letters, Vol. 377, No. 2, 29.03.2005, p. 81-84.

Research output: Contribution to journalArticle

Fung, HC, Evans, J, Evans, W, Duckworth, J, Pittman, A, De Silva, R, Myers, AJ & Hardy, J 2005, 'The architecture of the tau haplotype block in different ethnicities', Neuroscience Letters, vol. 377, no. 2, pp. 81-84. https://doi.org/10.1016/j.neulet.2004.11.072
Fung HC, Evans J, Evans W, Duckworth J, Pittman A, De Silva R et al. The architecture of the tau haplotype block in different ethnicities. Neuroscience Letters. 2005 Mar 29;377(2):81-84. https://doi.org/10.1016/j.neulet.2004.11.072
Fung, Hon Chung ; Evans, Jessica ; Evans, Whitney ; Duckworth, Jaime ; Pittman, Alan ; De Silva, Rohan ; Myers, Amanda J ; Hardy, John. / The architecture of the tau haplotype block in different ethnicities. In: Neuroscience Letters. 2005 ; Vol. 377, No. 2. pp. 81-84.
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