Abstract
We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.
Original language | English |
---|---|
Pages (from-to) | 81-84 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 377 |
Issue number | 2 |
DOIs | |
State | Published - Mar 29 2005 |
Externally published | Yes |
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Keywords
- FTDP-17
- Linkage disequilibrium
- MAPT gene
- Populations genetics
- Progressive supranuclear palsy
- Tau
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The architecture of the tau haplotype block in different ethnicities. / Fung, Hon Chung; Evans, Jessica; Evans, Whitney; Duckworth, Jaime; Pittman, Alan; De Silva, Rohan; Myers, Amanda J; Hardy, John.
In: Neuroscience Letters, Vol. 377, No. 2, 29.03.2005, p. 81-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The architecture of the tau haplotype block in different ethnicities
AU - Fung, Hon Chung
AU - Evans, Jessica
AU - Evans, Whitney
AU - Duckworth, Jaime
AU - Pittman, Alan
AU - De Silva, Rohan
AU - Myers, Amanda J
AU - Hardy, John
PY - 2005/3/29
Y1 - 2005/3/29
N2 - We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.
AB - We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of ∼2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.
KW - FTDP-17
KW - Linkage disequilibrium
KW - MAPT gene
KW - Populations genetics
KW - Progressive supranuclear palsy
KW - Tau
UR - http://www.scopus.com/inward/record.url?scp=14644440480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644440480&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2004.11.072
DO - 10.1016/j.neulet.2004.11.072
M3 - Article
C2 - 15740841
AN - SCOPUS:14644440480
VL - 377
SP - 81
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -