The architecture of the active zone in the presynaptic nerve terminal

Rong G Zhai, Hugo J. Bellen

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Active zones are highly specialized sites for release of neurotransmitter from presynaptic nerve terminals. The architecture of the active zone is exquisitely designed to facilitate the regulated tethering, docking, and fusing of the synaptic vesicles with the plasma membrane. Here we present our view of the structural and molecular organization of active zones across species and propose that all active zones are organized according to a common principle in which the structural differences correlate with the kinetics of transmitter release.

Original languageEnglish
Pages (from-to)262-270
Number of pages9
JournalPhysiology
Volume19
Issue number5
StatePublished - Oct 1 2004
Externally publishedYes

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Synaptic Vesicles
Presynaptic Terminals
Neurotransmitter Agents
Cell Membrane

ASJC Scopus subject areas

  • Physiology

Cite this

The architecture of the active zone in the presynaptic nerve terminal. / Zhai, Rong G; Bellen, Hugo J.

In: Physiology, Vol. 19, No. 5, 01.10.2004, p. 262-270.

Research output: Contribution to journalArticle

Zhai, Rong G ; Bellen, Hugo J. / The architecture of the active zone in the presynaptic nerve terminal. In: Physiology. 2004 ; Vol. 19, No. 5. pp. 262-270.
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