The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

Francesco Pichi, David Sarraf, Sruthi Arepalli, Careen Y. Lowder, Emmett T. Cunningham, Piergiorgio Neri, Thomas A Albini, Vishali Gupta, Kimberly Baynes, Sunil K. Srivastava

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse. This review aims to establish the basis of OCTA and its current application to ocular inflammatory disorders, with an emphasis on monitoring progression and response to treatment, as well as predicting visual complications. In particular, this review explores the use of OCTA in iris vessel dilation seen in various forms of iritis, as a predictive factor for further episodes of inflammation. OCTA can also depict ischemia in the deep plexus layers of the retina and identify true choroicapillaris ischemia in cases of placoid diseases or masking of the indocyanine green dye, as in multiple evanescent white dot syndrome. In addition, OCTA can depict neovascularization in granulomatous disease of the retina or choroid not previously depicted with previous imaging methods. While OCTA provides several advancements in the imaging, management and prognosis of uveitis diseases, we emphasize that further studies are required to fully understand its application to these conditions.

Original languageEnglish (US)
Pages (from-to)178-201
Number of pages24
JournalProgress in Retinal and Eye Research
Volume59
DOIs
StatePublished - Jul 1 2017

Fingerprint

Eye Diseases
Uveitis
Optical Coherence Tomography
Angiography
Retina
Coloring Agents
Ischemia
Iritis
Indocyanine Green
Choroid
Iris
Intravenous Administration
Dilatation
Inflammation
Light

Keywords

  • Anterior uveitis
  • Chorioretinal inflammation
  • Optical coherence tomography angiography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Pichi, F., Sarraf, D., Arepalli, S., Lowder, C. Y., Cunningham, E. T., Neri, P., ... Srivastava, S. K. (2017). The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. Progress in Retinal and Eye Research, 59, 178-201. https://doi.org/10.1016/j.preteyeres.2017.04.005

The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. / Pichi, Francesco; Sarraf, David; Arepalli, Sruthi; Lowder, Careen Y.; Cunningham, Emmett T.; Neri, Piergiorgio; Albini, Thomas A; Gupta, Vishali; Baynes, Kimberly; Srivastava, Sunil K.

In: Progress in Retinal and Eye Research, Vol. 59, 01.07.2017, p. 178-201.

Research output: Contribution to journalReview article

Pichi, F, Sarraf, D, Arepalli, S, Lowder, CY, Cunningham, ET, Neri, P, Albini, TA, Gupta, V, Baynes, K & Srivastava, SK 2017, 'The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases', Progress in Retinal and Eye Research, vol. 59, pp. 178-201. https://doi.org/10.1016/j.preteyeres.2017.04.005
Pichi, Francesco ; Sarraf, David ; Arepalli, Sruthi ; Lowder, Careen Y. ; Cunningham, Emmett T. ; Neri, Piergiorgio ; Albini, Thomas A ; Gupta, Vishali ; Baynes, Kimberly ; Srivastava, Sunil K. / The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. In: Progress in Retinal and Eye Research. 2017 ; Vol. 59. pp. 178-201.
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