The application of molecular techniques to solid tumors

Sean L. O'Connor, Jeong Hee Cho, Timothy J. McDonnell

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Recent developments in the field of molecular biology including the sequencing of the human genome and related high throughput methodologies are presenting the diagnostic pathologist with new opportunities to expand our understanding of human disease. These techniques enable the comprehensive assessment of molecular alterations with cell populations of interest, including cancer. It will be necessary for the diagnostic pathologist to become familiar with these techniques to effectively translate their potential into the clinical environment.

Original languageEnglish (US)
Pages (from-to)94-103
Number of pages10
JournalSeminars in Diagnostic Pathology
Volume19
Issue number2
StatePublished - May 20 2002
Externally publishedYes

Keywords

  • Comparative genomic hybridization
  • Fluorescent in situ hybridization
  • Laser capture microscopy
  • Proteomics
  • Reverse transcription polymerase reaction
  • Serial analysis of gene expression
  • Single nucleotide polymorphisms
  • Tissue microarrays
  • cDNA arrays

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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