The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

Jessica N. Cooke Bailey, Joshua D. Hoffman, Rebecca J. Sardell, William K. Scott, Margaret A. Pericak-Vance, Jonathan L. Haines

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.

Original languageEnglish (US)
Article number31
JournalJournal of Clinical Medicine
Volume5
Issue number3
DOIs
StatePublished - Mar 4 2016
Externally publishedYes

Keywords

  • Age-related macular degeneration (AMD)
  • Genetics
  • Risk score

ASJC Scopus subject areas

  • Medicine(all)

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