The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis

Caio Victor de Sousa, Marcelo Magalhães Sales, Thiago Santos Rosa, John E Lewis, Rosangela Vieira de Andrade, Herbert Gustavo Simões

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Background: Physical activity has been associated with reduced oxidative stress (OS) in observational studies and clinical trials. Objective: The purpose of this systematic review and meta-analysis of controlled trials was to determine the effect of physical exercise on OS parameters. Methods: We conducted a systematic review of the literature up to March 2016 that included the following databases: PubMed, SCOPUS, and Web of Science. A keyword combination referring to exercise training and OS was included as part of a more thorough search process. We also manually searched the reference lists of the articles. From an initial 1573 references, we included 30 controlled trials (1346 participants) in the qualitative analysis, 19 of which were included in the meta-analysis. All trials were conducted in humans and had at least one exercise intervention and a paired control group. Using a standardized protocol, two investigators independently abstracted data on study design, sample size, participant characteristics, intervention, follow-up duration, outcomes, and quantitative data for the meta-analysis. Thus, the investigators independently assigned quality scores with a methodological quality assessment (MQA). Results: The agreement level between the reviewers was 85.3 %. Discrepancies were solved in a consensus meeting. The MQA showed a total score in the quality index between 40 and 90 % and a mean quality of 55 %. Further, in a random-effects model, data from each trial were pooled and weighted by the inverse of the total variance. Physical training was associated with a significant reduction in pro-oxidant parameters (standard mean difference [SMD] –1.08; 95 % confidence interval [CI] –1.57 to –0.58; p < 0.001) and an increase in antioxidant capacity (SMD 1.45; 95 % CI 0.83–2.06; p < 0.001). Conclusion: The pooled analysis revealed that regardless of intensity, volume, type of exercise, and studied population, the antioxidant indicators tended to increase and pro-oxidant indicators tended to decrease after training. Therefore, we conclude that exercise training seems to induce an antioxidant effect. Thus, it is suggested that people practice some kind of exercise to balance the redox state, regardless of their health status, to improve health-related outcomes.

Original languageEnglish (US)
Pages (from-to)277-293
Number of pages17
JournalSports Medicine
Volume47
Issue number2
DOIs
StatePublished - Feb 1 2017

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Meta-Analysis
Oxidative Stress
Antioxidants
Exercise
Reactive Oxygen Species
Research Personnel
Confidence Intervals
PubMed
Sample Size
Health Status
Oxidation-Reduction
Observational Studies
Clinical Trials
Databases
Control Groups
Health
Population

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

de Sousa, C. V., Sales, M. M., Rosa, T. S., Lewis, J. E., de Andrade, R. V., & Simões, H. G. (2017). The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis. Sports Medicine, 47(2), 277-293. https://doi.org/10.1007/s40279-016-0566-1

The Antioxidant Effect of Exercise : A Systematic Review and Meta-Analysis. / de Sousa, Caio Victor; Sales, Marcelo Magalhães; Rosa, Thiago Santos; Lewis, John E; de Andrade, Rosangela Vieira; Simões, Herbert Gustavo.

In: Sports Medicine, Vol. 47, No. 2, 01.02.2017, p. 277-293.

Research output: Contribution to journalReview article

de Sousa, CV, Sales, MM, Rosa, TS, Lewis, JE, de Andrade, RV & Simões, HG 2017, 'The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis', Sports Medicine, vol. 47, no. 2, pp. 277-293. https://doi.org/10.1007/s40279-016-0566-1
de Sousa CV, Sales MM, Rosa TS, Lewis JE, de Andrade RV, Simões HG. The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis. Sports Medicine. 2017 Feb 1;47(2):277-293. https://doi.org/10.1007/s40279-016-0566-1
de Sousa, Caio Victor ; Sales, Marcelo Magalhães ; Rosa, Thiago Santos ; Lewis, John E ; de Andrade, Rosangela Vieira ; Simões, Herbert Gustavo. / The Antioxidant Effect of Exercise : A Systematic Review and Meta-Analysis. In: Sports Medicine. 2017 ; Vol. 47, No. 2. pp. 277-293.
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