The anti-inflammatory effects of exercise in the syndromic thread of diabetes and autoimmunity

R. Codella, L. Luzi, Luca A Inverardi, Camillo Ricordi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A unifying thread over the wide spectrum of diabetes might be the triggering of innate immunological and inflammatory pathways leading to insulin resistance, β-cell dysfunction and β-cell destruction: the hybrid features of type 1 and type 2 diabetes. In fact, hyperglycemia can arise from a deficit in insulin action, insulin secretion, or both. Regularly exercising at moderate intensity has been shown to efficiently and positively impact upon physiological imbalances caused by several morbid conditions. Even in different immunological dysfunctions, physical exercise has been prescribed as a complementary therapeutic strategy. In fact, as suggested by our observations, there is a putative inverse relationship between autoimmunity markers (GAD, IA) and exercise-derived energy expenditure in type 1 pre-diabetic subjects. Exercise also has been shown to maintain muscle mitochondrial function and thus ability to maintain fuel metabolism and islet cell function. An additional benefit is the enhancement of antioxidant defense system and thus reducing oxidative stress. Therefore, the purpose of this review is to address the importance of physical exercise in a broad range of metabolic disorders that set out a common milieu in which type 1 and type 2 diabetes could be identified as one extensive syndrome.

Original languageEnglish (US)
Pages (from-to)3709-3722
Number of pages14
JournalEuropean Review for Medical and Pharmacological Sciences
Volume19
Issue number19
StatePublished - 2015

Fingerprint

Autoimmunity
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Anti-Inflammatory Agents
Exercise
Insulin
Hybrid Cells
Islets of Langerhans
Hyperglycemia
Energy Metabolism
Insulin Resistance
Oxidative Stress
Antioxidants
Muscles
Therapeutics

Keywords

  • Adipokines
  • Autoimmunity
  • Cytokines
  • Diabetes
  • Exercise
  • Immunometabolism
  • Inflammation
  • Myokines

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

The anti-inflammatory effects of exercise in the syndromic thread of diabetes and autoimmunity. / Codella, R.; Luzi, L.; Inverardi, Luca A; Ricordi, Camillo.

In: European Review for Medical and Pharmacological Sciences, Vol. 19, No. 19, 2015, p. 3709-3722.

Research output: Contribution to journalArticle

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