The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: A study in a baboon model of diabetes

V. L. Perez, A. Caicedo, D. M. Berman, E. Arrieta, M. H. Abdulreda, R. Rodriguez-Diaz, A. Pileggi, E. Hernandez, S. R. Dubovy, J. M. Parel, C. Ricordi, N. M. Kenyon, N. S. Kenyon, P. O. Berggren

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Aims/hypothesis: The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. Methods: In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed. Results: Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period. Conclusions/interpretation: Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.

Original languageEnglish (US)
Pages (from-to)1121-1126
Number of pages6
JournalDiabetologia
Volume54
Issue number5
DOIs
StatePublished - May 1 2011

Keywords

  • Allogeneic
  • Anterior chamber of the eye
  • Baboon
  • Diabetes
  • Immune privilege
  • Islet transplantation
  • Streptozotocin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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