The analysis of carcinomas of the vagina for human papillomavirus DNA

R. S. Ostrow, D. A. Manias, B. A. Clark, M. Fukushima, T. Okagaki, L. B. Twiggs, A. J. Faras

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Invasive cancers of the vagina are relatively rare and often resistant to effective treatment. While studies on the more abundant premalignant lesions of the vagina and premalignant and malignant tumors of the vulva and cervix have shown a frequent association with human papillomavirus (HPV) DNA infection, lack of fresh tissue samples has precluded similar studies on malignant tumors of the vagina. Using mostly in situ hybridization, we have retroactively examined 14 formalin-fixed, paraffin-embedded biopsies of invasive squamous cell carcinomas of the vagina. We have found 21% of the samples to have HPV DNA. These findings confirm a role for HPV in malignancies of the entire female lower general tract.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume7
Issue number4
StatePublished - Dec 1 1988
Externally publishedYes

Fingerprint

Vagina
Carcinoma
DNA
Vaginal Neoplasms
Neoplasms
Vulva
Papillomavirus Infections
Cervix Uteri
Paraffin
Formaldehyde
In Situ Hybridization
Squamous Cell Carcinoma
Biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Ostrow, R. S., Manias, D. A., Clark, B. A., Fukushima, M., Okagaki, T., Twiggs, L. B., & Faras, A. J. (1988). The analysis of carcinomas of the vagina for human papillomavirus DNA. International Journal of Gynecological Pathology, 7(4), 308-314.

The analysis of carcinomas of the vagina for human papillomavirus DNA. / Ostrow, R. S.; Manias, D. A.; Clark, B. A.; Fukushima, M.; Okagaki, T.; Twiggs, L. B.; Faras, A. J.

In: International Journal of Gynecological Pathology, Vol. 7, No. 4, 01.12.1988, p. 308-314.

Research output: Contribution to journalArticle

Ostrow, RS, Manias, DA, Clark, BA, Fukushima, M, Okagaki, T, Twiggs, LB & Faras, AJ 1988, 'The analysis of carcinomas of the vagina for human papillomavirus DNA', International Journal of Gynecological Pathology, vol. 7, no. 4, pp. 308-314.
Ostrow RS, Manias DA, Clark BA, Fukushima M, Okagaki T, Twiggs LB et al. The analysis of carcinomas of the vagina for human papillomavirus DNA. International Journal of Gynecological Pathology. 1988 Dec 1;7(4):308-314.
Ostrow, R. S. ; Manias, D. A. ; Clark, B. A. ; Fukushima, M. ; Okagaki, T. ; Twiggs, L. B. ; Faras, A. J. / The analysis of carcinomas of the vagina for human papillomavirus DNA. In: International Journal of Gynecological Pathology. 1988 ; Vol. 7, No. 4. pp. 308-314.
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