The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample

Fiona Crawford, Terrence Town, Melissa Freeman, John Schinka, Michael Gold, Ranjan Duara, Mike Mullan

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Genetic association has recently been reported between alleles in the alpha-2-macroglobulin (A2M) gene and the occurrence of Alzheimer's disease (AD) in familial and sporadic samples. We have investigated the A2M intronic deletion polymorphism in a case-control study of 295 unrelated clinic and community-based AD cases, and compared these to a sample of 113 unrelated control individuals recruited as part of an epidemiological study. Our results show no association between A2M and AD in either case sample. Furthermore, A2M is not predictive of AD in an interactive fashion when considering APOE, race or gender. In a subset of our larger sample we have also investigated the A2M Val1000lle polymorphism, and again find not evidence for association. We conclude that there is no genetic association between A2M and AD in our case-control sample.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalNeuroscience Letters
Volume270
Issue number3
DOIs
StatePublished - Aug 6 1999
Externally publishedYes

Keywords

  • β- Amyloid
  • Alpha-2 macroglobulin
  • Alzheimer's disease
  • Genetic association

ASJC Scopus subject areas

  • Neuroscience(all)

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