TY - JOUR
T1 - The aging risk and atherosclerosis
T2 - A fresh look at arterial homeostasis
AU - Head, Trajen
AU - Daunert, Sylvia
AU - Goldschmidt-Clermont, Pascal J.
N1 - Funding Information:
SD is grateful to the Miller School of Medicine of the University of Miami for the Lucille P. Markey Chair in the Department of Biochemistry and Molecular Biology
Publisher Copyright:
© 2017 Head, Daunert and Goldschmidt-Clermont.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/12/14
Y1 - 2017/12/14
N2 - A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is the dominant risk factor for clinically significant atherosclerotic lesion formation, yet the heightened impact of aging on the disease is not accounted for by changes in traditional risk factors, such as lack of physical activity, smoking, hypertension, hyperlipidemia, or diabetes mellitus. This review will examine the pathological and biochemical processes of atherosclerotic plaque formation and growth, with particular focus on the aging risk vis-a-vis arterial homeostasis. Particular focus will be placed on the impact of a number of important contributors to arterial homeostasis including bone marrow (BM)-derived vascular progenitor cells, differential monocyte subpopulations, and the role of cellular senescence. Finally, this review will explore many critical observations in the way the disease process has been reassessed both by clinicians and researchers, and will highlight recent advances in this field that have provided a greater understanding of this aging-driven disease.
AB - A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is the dominant risk factor for clinically significant atherosclerotic lesion formation, yet the heightened impact of aging on the disease is not accounted for by changes in traditional risk factors, such as lack of physical activity, smoking, hypertension, hyperlipidemia, or diabetes mellitus. This review will examine the pathological and biochemical processes of atherosclerotic plaque formation and growth, with particular focus on the aging risk vis-a-vis arterial homeostasis. Particular focus will be placed on the impact of a number of important contributors to arterial homeostasis including bone marrow (BM)-derived vascular progenitor cells, differential monocyte subpopulations, and the role of cellular senescence. Finally, this review will explore many critical observations in the way the disease process has been reassessed both by clinicians and researchers, and will highlight recent advances in this field that have provided a greater understanding of this aging-driven disease.
KW - Aging
KW - Arterial homeostasis
KW - Atherosclerosis
KW - Bone marrow-derived vascular progenitor cells
KW - Cardiovascular disease
KW - Risk factors
KW - Vascular repair
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U2 - 10.3389/fgene.2017.00216
DO - 10.3389/fgene.2017.00216
M3 - Review article
AN - SCOPUS:85037997614
VL - 8
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
IS - DEC
M1 - 216
ER -