The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity

Shohreh F. Farzan, Samer Singh, Neal S. Schilling, David J Robbins

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given its wide role in development, as well as in a variety of disease states, understanding the regulation of Hh function and activity is critically important. However, the study of Hh signaling has been impeded by its unusual biology. Hh is unique in that it is the only protein covalently modified by cholesterol, which in turn affects numerous aspects of its localization, release, movement, and activity. All are important factors when considering Hh's physiological role, and animals have developed an intricate system of regulators responsible for both promoting and inhibiting the activity of Hh. This review is intended to give a broad overview of how the biosynthesis and movement of Hh contributes to its biological activity.

Original languageEnglish
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume294
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Hedgehogs
Mitogens
Gastrointestinal Tract
Cell Survival
Proteins
Cholesterol
Maintenance

Keywords

  • Morphogen
  • Review

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity. / Farzan, Shohreh F.; Singh, Samer; Schilling, Neal S.; Robbins, David J.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 294, No. 4, 01.04.2008.

Research output: Contribution to journalArticle

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