The adrenal gland is a source of stress-induced circulating IL-18

Shuei Sugama; Ning Wang; Noriaki Shimokawa; Noriyuki Koibuchi; Masayo Fujita; Makoto Hashimoto; Firdaus S. Dhabhar; Bruno Conti

doi:10.1016/j.jneuroim.2005.11.001

The adrenal gland is a source of stress-induced circulating IL-18

Shuei Sugama, Ning Wang, Noriaki Shimokawa, Noriyuki Koibuchi, Masayo Fujita, Makoto Hashimoto, Firdaus S. Dhabhar, Bruno Conti

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.

Original language	English (US)
Pages (from-to)	59-65
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	172
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.11.001
State	Published - Mar 2006
Externally published	Yes

Keywords

Adrenal gland
Adrenalectomy
HPA axis
Immobilization stress
Interleukin-18

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2005.11.001

Fingerprint Dive into the research topics of 'The adrenal gland is a source of stress-induced circulating IL-18'. Together they form a unique fingerprint.

Cite this

@article{1cb7238d2eff43fd8f6829e8350800bc,

title = "The adrenal gland is a source of stress-induced circulating IL-18",

abstract = "The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.",

keywords = "Adrenal gland, Adrenalectomy, HPA axis, Immobilization stress, Interleukin-18",

author = "Shuei Sugama and Ning Wang and Noriaki Shimokawa and Noriyuki Koibuchi and Masayo Fujita and Makoto Hashimoto and Dhabhar, {Firdaus S.} and Bruno Conti",

note = "Funding Information: This study was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to S.S. Corresponding author sincerely wish to thank Dr. T. Shibasaki for valuable suggestions and Dr. H. Ohata for technical supports.",

year = "2006",

month = mar,

doi = "10.1016/j.jneuroim.2005.11.001",

language = "English (US)",

volume = "172",

pages = "59--65",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - The adrenal gland is a source of stress-induced circulating IL-18

AU - Sugama, Shuei

AU - Wang, Ning

AU - Shimokawa, Noriaki

AU - Koibuchi, Noriyuki

AU - Fujita, Masayo

AU - Hashimoto, Makoto

AU - Dhabhar, Firdaus S.

AU - Conti, Bruno

N1 - Funding Information: This study was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to S.S. Corresponding author sincerely wish to thank Dr. T. Shibasaki for valuable suggestions and Dr. H. Ohata for technical supports.

PY - 2006/3

Y1 - 2006/3

N2 - The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.

AB - The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.

KW - Adrenal gland

KW - Adrenalectomy

KW - HPA axis

KW - Immobilization stress

KW - Interleukin-18

UR - http://www.scopus.com/inward/record.url?scp=33244491236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33244491236&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2005.11.001

DO - 10.1016/j.jneuroim.2005.11.001

M3 - Article

C2 - 16359733

AN - SCOPUS:33244491236

VL - 172

SP - 59

EP - 65

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

The adrenal gland is a source of stress-induced circulating IL-18

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this