The adrenal gland is a source of stress-induced circulating IL-18

Shuei Sugama, Ning Wang, Noriaki Shimokawa, Noriyuki Koibuchi, Masayo Fujita, Makoto Hashimoto, Firdaus S. Dhabhar, Bruno Conti

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Mar 2006
Externally publishedYes


  • Adrenal gland
  • Adrenalectomy
  • HPA axis
  • Immobilization stress
  • Interleukin-18

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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