The Acute Retinal Necrosis Syndrome: Part 2: Histopathology and Etiology

William W. Culbertson, Mark S. Blumenkranz, Harold Haines, J. Donald M. Gass, Kenneth B. Mitchell, Edward W.D. Norton

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

The acute retinal necrosis syndrome is manifested by diffuse uveitis, vitritis, retinal vasculitis, and acute necrotizing retinitis (see Part 1). We studied the histopathology and electron microscopic findings of an eye enucleated from a 67-year-old man with typical acute retinal necrosis. Histology showed profound acute necrosis of the retina, retinal arteritis, and eosinophilic intranuclear inclusions in retinal cells. Electron microscopy demonstrated a herpes group virus in all layers of affected retina. The implications of these findings for antiviral and other treatments are discussed.

Original languageEnglish (US)
Pages (from-to)1317-1325
Number of pages9
JournalOphthalmology
Volume89
Issue number12
DOIs
StatePublished - Jan 1 1982

Keywords

  • acute retinal necrosis
  • cytomegalovirus
  • herpes simplex
  • herpes zoster
  • herpesvirus
  • retina
  • retinal necrosis
  • retinal vasculitis
  • retinitis
  • uveitis
  • viral retinitis
  • vitritis

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'The Acute Retinal Necrosis Syndrome: Part 2: Histopathology and Etiology'. Together they form a unique fingerprint.

  • Cite this

    Culbertson, W. W., Blumenkranz, M. S., Haines, H., Gass, J. D. M., Mitchell, K. B., & Norton, E. W. D. (1982). The Acute Retinal Necrosis Syndrome: Part 2: Histopathology and Etiology. Ophthalmology, 89(12), 1317-1325. https://doi.org/10.1016/S0161-6420(82)34638-2