The acute retinal necrosis syndrome. Part 2: Histopathology and etiology

William W Culbertson, M. S. Blumenkranz, H. Haines, D. M. Gass, K. B. Mitchell, E. W. Norton

Research output: Contribution to journalArticle

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Abstract

The acute retinal necrosis syndrome is manifested by diffuse uveitis, vitritis, retinal vasculitis, and acute necrotizing retinitis (see Part 1). We studied the histopathology and electron microscopic findings of an eye enucleated from a 67-year-old man with typical acute retinal necrosis. Histology showed profound acute necrosis of the retina, retinal arteritis, and eosinophilic intranuclear inclusions in retinal cells. Electron microscopy demonstrated a herpes group virus in all layers of affected retina. The implications of these findings for antiviral and other treatments are discussed.

Original languageEnglish
Pages (from-to)1317-1325
Number of pages9
JournalOphthalmology
Volume89
Issue number12
StatePublished - Dec 1 1982

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Acute Retinal Necrosis Syndrome
Retina
Retinal Vasculitis
Retinitis
Intranuclear Inclusion Bodies
Arteritis
Uveitis
Antiviral Agents
Histology
Electron Microscopy
Electrons
Viruses
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Culbertson, W. W., Blumenkranz, M. S., Haines, H., Gass, D. M., Mitchell, K. B., & Norton, E. W. (1982). The acute retinal necrosis syndrome. Part 2: Histopathology and etiology. Ophthalmology, 89(12), 1317-1325.

The acute retinal necrosis syndrome. Part 2 : Histopathology and etiology. / Culbertson, William W; Blumenkranz, M. S.; Haines, H.; Gass, D. M.; Mitchell, K. B.; Norton, E. W.

In: Ophthalmology, Vol. 89, No. 12, 01.12.1982, p. 1317-1325.

Research output: Contribution to journalArticle

Culbertson, WW, Blumenkranz, MS, Haines, H, Gass, DM, Mitchell, KB & Norton, EW 1982, 'The acute retinal necrosis syndrome. Part 2: Histopathology and etiology', Ophthalmology, vol. 89, no. 12, pp. 1317-1325.
Culbertson WW, Blumenkranz MS, Haines H, Gass DM, Mitchell KB, Norton EW. The acute retinal necrosis syndrome. Part 2: Histopathology and etiology. Ophthalmology. 1982 Dec 1;89(12):1317-1325.
Culbertson, William W ; Blumenkranz, M. S. ; Haines, H. ; Gass, D. M. ; Mitchell, K. B. ; Norton, E. W. / The acute retinal necrosis syndrome. Part 2 : Histopathology and etiology. In: Ophthalmology. 1982 ; Vol. 89, No. 12. pp. 1317-1325.
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