The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation

Youssef Zeidan, Y. A. Hannun

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase (ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the phosphocholine head group of sphingomyelin to generate ceramide. Cumulative efforts of various laboratories over the past 40 years have placed ASMase and its product ceramide at the forefront of lipid research. Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFα, TRAIL, Fas ligand), cytokines (IL-1, IFNγ), radiation, pathogenic infections, cytotoxic agents and others. The strategic role of ASMase in lipid metabolism and cellular stress response has sparked interest in investigatig the molecular mechanisms underlying ASMase activation. In this article, we review the translational role of the ASMase/ceramide pathway and recent advances on its mechanisms of regulation.

Original languageEnglish (US)
Pages (from-to)454-466
Number of pages13
JournalCurrent Molecular Medicine
Volume10
Issue number5
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Sphingomyelin Phosphodiesterase
Ceramides
Acids
Chemical activation
Sphingolipids
Fas Ligand Protein
Phosphorylcholine
Sphingomyelins
Cytotoxins
Type C Phospholipases
Interleukin-1
Lipid Metabolism
Radiation
Cytokines
Ligands
Lipids
Enzymes
Infection
Research

Keywords

  • Apoptosis
  • Cancer
  • Ceramide
  • Membranes and sphingolipid
  • Protein kinase c
  • Sphingomyelinase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Medicine(all)

Cite this

The acid sphingomyelinase/ceramide pathway : Biomedical significance and mechanisms of regulation. / Zeidan, Youssef; Hannun, Y. A.

In: Current Molecular Medicine, Vol. 10, No. 5, 2010, p. 454-466.

Research output: Contribution to journalArticle

@article{b5e7910aae9d4dc28e9d33ccced57ad6,
title = "The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation",
abstract = "One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase (ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the phosphocholine head group of sphingomyelin to generate ceramide. Cumulative efforts of various laboratories over the past 40 years have placed ASMase and its product ceramide at the forefront of lipid research. Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFα, TRAIL, Fas ligand), cytokines (IL-1, IFNγ), radiation, pathogenic infections, cytotoxic agents and others. The strategic role of ASMase in lipid metabolism and cellular stress response has sparked interest in investigatig the molecular mechanisms underlying ASMase activation. In this article, we review the translational role of the ASMase/ceramide pathway and recent advances on its mechanisms of regulation.",
keywords = "Apoptosis, Cancer, Ceramide, Membranes and sphingolipid, Protein kinase c, Sphingomyelinase",
author = "Youssef Zeidan and Hannun, {Y. A.}",
year = "2010",
doi = "10.2174/156652410791608225",
language = "English (US)",
volume = "10",
pages = "454--466",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - The acid sphingomyelinase/ceramide pathway

T2 - Biomedical significance and mechanisms of regulation

AU - Zeidan, Youssef

AU - Hannun, Y. A.

PY - 2010

Y1 - 2010

N2 - One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase (ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the phosphocholine head group of sphingomyelin to generate ceramide. Cumulative efforts of various laboratories over the past 40 years have placed ASMase and its product ceramide at the forefront of lipid research. Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFα, TRAIL, Fas ligand), cytokines (IL-1, IFNγ), radiation, pathogenic infections, cytotoxic agents and others. The strategic role of ASMase in lipid metabolism and cellular stress response has sparked interest in investigatig the molecular mechanisms underlying ASMase activation. In this article, we review the translational role of the ASMase/ceramide pathway and recent advances on its mechanisms of regulation.

AB - One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase (ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the phosphocholine head group of sphingomyelin to generate ceramide. Cumulative efforts of various laboratories over the past 40 years have placed ASMase and its product ceramide at the forefront of lipid research. Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFα, TRAIL, Fas ligand), cytokines (IL-1, IFNγ), radiation, pathogenic infections, cytotoxic agents and others. The strategic role of ASMase in lipid metabolism and cellular stress response has sparked interest in investigatig the molecular mechanisms underlying ASMase activation. In this article, we review the translational role of the ASMase/ceramide pathway and recent advances on its mechanisms of regulation.

KW - Apoptosis

KW - Cancer

KW - Ceramide

KW - Membranes and sphingolipid

KW - Protein kinase c

KW - Sphingomyelinase

UR - http://www.scopus.com/inward/record.url?scp=77954709548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954709548&partnerID=8YFLogxK

U2 - 10.2174/156652410791608225

DO - 10.2174/156652410791608225

M3 - Article

C2 - 20540705

AN - SCOPUS:77954709548

VL - 10

SP - 454

EP - 466

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 5

ER -