Th2 type cytokine profile in hiv infected children in relative good health who have ige against hiv virus proteins

Elizabeth A. Secord, Gary I. Kleiner, Daryl Jaggoo, Andrty H. Oliff, Domic I. Aucl, Seto Chice, Maio Nowakowski, Melen Durkin

Research output: Contribution to journalArticlepeer-review

Abstract

Serua IgE was elevatid (by age specific standards ) in 22% (11/39) of HIV infected children. The ethnicity of tne children reflected the clinic popula ion, 26/39 wen African American and 11/39 were Puerto Hi an. The children with elevated serin IgE did not have signi icantly different incidence of allergic symptoms than the children without serun IgE etevitton, i.e., 36% (4/11) of t e group with elevated IgE had a history of allergy (atopic dermatitis, asTnna, atlergic rhinitis, or drug rash), while 29% (8/28) of the group with normt to low IgE gave a similar history. IgE against HIV proteins was detected by western blotting in 4/11 of the children with elevated serum IgE, whose ages ranged from 8-12 years. Two of these chi Idren had IgE against gp160, and all four had IgE againt p24. None of these children with IgE against HIV had had documented opportunistic infections or failure to thrive. All four children were of the same ethnic origin (Puerto Rican), implying a genetic predisposition to the response. Peripheral blood Mononuclear cells have been isolated and analyzed for mRNA of Thl and Th2 type cytokines (PCR) in two of the children with IgE against HIV proteins, Both children had IL4 and IL10 mRNA in peripheral blood, i.e. Th2 type cytokine profite. Th2 cytokine profite and elevated IgE have been previously associated with progression of M1v disease. In these children described, IgE against HIV My oe a late compensatory response, conferring ar advantage even in the face of progressive NIV disease with 1,2 cytokine profile.

Original languageEnglish (US)
Pages (from-to)278
Number of pages1
JournalPediatric AIDS and HIV Infection
Volume7
Issue number4
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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