Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma

Yuhong Zhuo, Michael McLane, Roy C. Levitt

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (TH2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the TH2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other TH2 cytokines such as IL-4, IL-5 and IL-13.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalRespiratory research
Volume2
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Asthma
  • Genetics
  • Interleukin-9
  • Target
  • Transgenic

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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