Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma

Yuhong Zhuo, Michael McLane, Roy C Levitt

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (TH2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the TH2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other TH2 cytokines such as IL-4, IL-5 and IL-13.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalRespiratory Research
Volume2
Issue number2
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

Fingerprint

Interleukin-9
Asthma
Cytokines
Mucosal Immunity
Interleukin-13
Interleukin-5
Environmental Exposure
Helper-Inducer T-Lymphocytes
Interleukin-4
Therapeutics

Keywords

  • Asthma
  • Genetics
  • Interleukin-9
  • Target
  • Transgenic

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma. / Zhuo, Yuhong; McLane, Michael; Levitt, Roy C.

In: Respiratory Research, Vol. 2, No. 2, 01.12.2001, p. 80-84.

Research output: Contribution to journalArticle

Zhuo, Yuhong ; McLane, Michael ; Levitt, Roy C. / Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma. In: Respiratory Research. 2001 ; Vol. 2, No. 2. pp. 80-84.
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