TGF β1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve

Philippe P. Lefebvre, Didier Martin, Hinrich Staecker, Thierry Weber, Gustave Moonen, Thomas R. Van De Water

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGFβ1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGFβ1 is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFGβ1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalNeuroreport
Volume3
Issue number4
DOIs
StatePublished - Apr 1992

Keywords

  • Auditory neurons
  • Axotomy
  • TGFβ

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lefebvre, P. P., Martin, D., Staecker, H., Weber, T., Moonen, G., & Van De Water, T. R. (1992). TGF β1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve. Neuroreport, 3(4), 295-298. https://doi.org/10.1097/00001756-199204000-00001