TGFβ1 modulates bFGF receptor message expression in cultured adult auditory neurons

Philippe P. Lefebvre, Hinrich Staecker, Thierry Weber, Thomas R. Van de Water, Bernard Rogister, Gustave Moonen

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFβ1,) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFβ1 is expressed in cultured adult mouse auditory neurons in response to explantation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFβ1, and bFGF) play a significant role in the response to injury by the mature auditory system.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalNeuroreport
Volume2
Issue number6
DOIs
StatePublished - Jun 1991

Keywords

  • Auditory neurons
  • Basic fibroblast growth factor receptor
  • Injury
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Neuroscience(all)

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