TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve

P. P. Lefebvre, D. Martin, H. Staecker, T. Weber, G. Moonen, Thomas R Van De Water

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGFβ1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGFβ1 is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFGβ1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalNeuroReport
Volume3
Issue number4
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Cochlear Nerve
Neurons
Nerve Growth Factor
Vestibulocochlear Nerve
Spiral Ganglion
Nerve Growth Factors
Wounds and Injuries
Fibroblast Growth Factor 2
Transforming Growth Factor beta

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lefebvre, P. P., Martin, D., Staecker, H., Weber, T., Moonen, G., & Van De Water, T. R. (1992). TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve. NeuroReport, 3(4), 295-298.

TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve. / Lefebvre, P. P.; Martin, D.; Staecker, H.; Weber, T.; Moonen, G.; Van De Water, Thomas R.

In: NeuroReport, Vol. 3, No. 4, 01.01.1992, p. 295-298.

Research output: Contribution to journalArticle

Lefebvre, PP, Martin, D, Staecker, H, Weber, T, Moonen, G & Van De Water, TR 1992, 'TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve', NeuroReport, vol. 3, no. 4, pp. 295-298.
Lefebvre PP, Martin D, Staecker H, Weber T, Moonen G, Van De Water TR. TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve. NeuroReport. 1992 Jan 1;3(4):295-298.
Lefebvre, P. P. ; Martin, D. ; Staecker, H. ; Weber, T. ; Moonen, G. ; Van De Water, Thomas R. / TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve. In: NeuroReport. 1992 ; Vol. 3, No. 4. pp. 295-298.
@article{edbfb619686748428e34c9a83406b85b,
title = "TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve",
abstract = "Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGFβ1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGFβ1 is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFGβ1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system.",
author = "Lefebvre, {P. P.} and D. Martin and H. Staecker and T. Weber and G. Moonen and {Van De Water}, {Thomas R}",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "3",
pages = "295--298",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - TGFβ1 expression is initiated in adult auditory neurons by sectioning of the auditory nerve

AU - Lefebvre, P. P.

AU - Martin, D.

AU - Staecker, H.

AU - Weber, T.

AU - Moonen, G.

AU - Van De Water, Thomas R

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGFβ1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGFβ1 is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFGβ1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system.

AB - Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGFβ1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGFβ1 is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFGβ1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system.

UR - http://www.scopus.com/inward/record.url?scp=0026590273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026590273&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 295

EP - 298

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 4

ER -