Tetraspanins expressed in the embryonic chick nervous system

Jeanette C. Perron, John L. Bixby

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG-2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalFEBS letters
Volume461
Issue number1-2
DOIs
StatePublished - Nov 12 1999

    Fingerprint

Keywords

  • Avian
  • Brain
  • Development
  • Sensory neuron
  • Spinal cord
  • Tetraspanin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this