Abstract
Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG-2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).
| Original language | English |
|---|---|
| Pages (from-to) | 86-90 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 461 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 12 1999 |
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Keywords
- Avian
- Brain
- Development
- Sensory neuron
- Spinal cord
- Tetraspanin
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Tetraspanins expressed in the embryonic chick nervous system. / Perron, Jeanette C.; Bixby, John.
In: FEBS Letters, Vol. 461, No. 1-2, 12.11.1999, p. 86-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tetraspanins expressed in the embryonic chick nervous system
AU - Perron, Jeanette C.
AU - Bixby, John
PY - 1999/11/12
Y1 - 1999/11/12
N2 - Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG-2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).
AB - Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG-2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).
KW - Avian
KW - Brain
KW - Development
KW - Sensory neuron
KW - Spinal cord
KW - Tetraspanin
UR - http://www.scopus.com/inward/record.url?scp=0032748306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032748306&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(99)01429-5
DO - 10.1016/S0014-5793(99)01429-5
M3 - Article
VL - 461
SP - 86
EP - 90
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1-2
ER -