TET family proteins and their role in stem cell differentiation and transformation

Luisa Cimmino, Omar Abdel-Wahab, Ross L. Levine, Iannis Aifantis

Research output: Contribution to journalReview articlepeer-review

166 Scopus citations

Abstract

One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation.

Original languageEnglish (US)
Pages (from-to)193-204
Number of pages12
JournalCell Stem Cell
Volume9
Issue number3
DOIs
StatePublished - Sep 2 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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