Testosterone supplementation versus clomiphene citrate for hypogonadism: An age matched comparison of satisfaction and efficacy

Ranjith Ramasamy, Jason M. Scovell, Jason R. Kovac, Larry I. Lipshultz

Research output: Contribution to journalArticle

40 Scopus citations


Purpose We compared satisfaction and treatment efficacy in men with symptomatic hypogonadism who received clomiphene citrate or testosterone supplementation therapy. Materials and Methods Men treated with clomiphene citrate, or testosterone injections or gels for symptomatic hypogonadism (total testosterone less than 300 ng/dl) reported satisfaction with the current treatment regimen using the qADAM questionnaire. Results A total of 93 men on testosterone injections (31) or gels (31), or clomiphene citrate (31) were age matched from a retrospective cohort of 1,150 on testosterone supplementation therapy. We compared men who received testosterone supplementation therapy to 31 not on such therapy, who served as controls. Median serum testosterone increased from pretreatment levels in all men regardless of therapy with clomiphene citrate, and testosterone injections and gels (from 247 to 504, 224 to 1,104 and 230 to 412 ng/dl, respectively, p 0.05). Men receiving testosterone injections reported greater libido than men on clomiphene citrate (4 vs 3, p = 0.04) or testosterone gels (4 vs 3, p = 0.04), or controls (4 vs 3, p

Original languageEnglish (US)
Pages (from-to)875-879
Number of pages5
JournalJournal of Urology
Issue number3
StatePublished - 2014
Externally publishedYes



  • clomiphene
  • hypogonadism
  • questionnaires
  • testes
  • testosterone

ASJC Scopus subject areas

  • Urology

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