Testosterone and growth hormone normalization: A retrospective study of health outcomes

Enrique Ginzburg, Alvin Lin, Michael Sigler, Denise Olsen, Nancy Klimas, Alan Mintz

Research output: Contribution to journalArticlepeer-review


Background: Age-related declines in testosterone and growth hormone (GH) are associated with increased adiposity and decreases in lean mass and bone mineral density (BMD). A long-term retrospective study examined the effects of testosterone and/or GH supplementation on body composition and quality of life (QoL). Methods: A database survey assessed the records of 91 men and 97 women (ages 25–82) in treatment groups based on their hormonal status: dehydroepiandrosterone but no hormonal supplementation (control); testosterone only (Tes); GH only (GH); and testosterone plus GH (Tes+GH). Pre- and post-treatment assessments recorded changes in fat and lean mass, BMD, and QoL. Results: After an average of 3 years of treatment, weight decreased in women in the control and Tes+GH groups but remained stable in men in all groups. Tes and Tes+GH produced statistically significant increases in lean mass, reductions in fat mass, and improvements in BMD in both sexes; GH produced similar changes in women. QoL and mood improved in all groups. Treatments were generally safe and well tolerated. Conclusions: In this retrospective survey, treatment with testosterone and/or GH was associated with favorable effects in men and women across a wide age range.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalJournal of Multidisciplinary Healthcare
StatePublished - Sep 16 2008


  • Body composition
  • Growth hormone
  • Quality of life
  • Testosterone

ASJC Scopus subject areas

  • Nursing(all)


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