Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders

Richard K. Parrish, Joyce C. Schiffman, William J. Feuer, Douglas R. Anderson, Donald L. Budenz, Maria Cristina Wells-Albornoz, Ruth Vandenbroucke, Michael A. Kass, Mae O. Gordon

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

PURPOSE: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS). DESIGN: Test-retest reproducibility study. METHODS: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, regradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream. RESULTS: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%. CONCLUSIONS: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in regrading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.

Original languageEnglish (US)
Pages (from-to)762-764
Number of pages3
JournalAmerican journal of ophthalmology
Volume140
Issue number4
DOIs
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Ophthalmology

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    Parrish, R. K., Schiffman, J. C., Feuer, W. J., Anderson, D. R., Budenz, D. L., Wells-Albornoz, M. C., Vandenbroucke, R., Kass, M. A., & Gordon, M. O. (2005). Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders. American journal of ophthalmology, 140(4), 762-764. https://doi.org/10.1016/j.ajo.2005.04.044