Abstract
A series of bis(pyridinium)-xylylene derivatives bearing carboxylate terminal groups were investigated as guests for the cucurbit[7]uril host in aqueous solution. While the presence of the terminal carboxylates has a modest effect on the thermodynamic stability of the complexes, the kinetics of complex association/dissociation is strongly affected. The relative position (meta, para) of the carboxylate group in relation to the pyridinium nitrogen also exerts a considerable effect on the binding kinetics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2325-2329 |
| Number of pages | 5 |
| Journal | Journal of Organic Chemistry |
| Volume | 84 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 15 2019 |
ASJC Scopus subject areas
- Organic Chemistry
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Cite this
Neira, I., García, M. D., Peinador, C., & Kaifer, A. E. (2019). Terminal Carboxylate Effects on the Thermodynamics and Kinetics of Cucurbit[7]uril Binding to Guests Containing a Central Bis(Pyridinium)-Xylylene Site. Journal of Organic Chemistry, 84(4), 2325-2329. https://doi.org/10.1021/acs.joc.8b02993