Tenoxicam does not enhance the spread of sensory block produced by intrathecal lidocaine

A. Fassoulaki, Konstantinos D. Sarantopoulos, M. Zotou

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Systemic opioids enhance the spread of spinal analgesia. This study was designed to determine whether i.v. tenoxicam, a nonsteroidal anti- inflammatory drug (NSAID), affects the spread of sensory block produced by lidocaine. Sixty patients undergoing transurethral procedures were randomly assigned in a double blind design to receive i.v. either 3 ml normal saline (N/S group, n = 20), or 150 μg fentanyl (F group, n = 20), or 40 mg tenoxicam (T group, n = 20), 20 minutes after spinal anesthesia. The level of sensory loss was tested with pinprick sensation 20 minutes after subarachnoid block, but before i.v. treatment, and 5, 10, and 15 minutes after i.v. treatment. Five minutes after the i.v. treatment the change in the level of sensory block was -0.8 ± 3.1 cm in the N/S group, 4.0 ± 3.5 cm in the F group and 0.0 ± 3.9 cm in the T group. The changes in the height of sensory block among the three groups differed 5 minutes and 10 minutes (F = 10.627, df = 2.57, P < 0.001 and F = 4.219, df = 2,57, P < 0.05 respectively), but not 15 minutes after i.v. treatment. Individual comparisons showed a difference between the N/S and F groups (P < 0.01), and between the F and T groups (P < 0.01) 5 minutes after treatment, and between the N/S and F groups (P < 0.05) 10 minutes after treatment. The overall change in the level of sensory block 15 minutes after i.v. treatment was - 4.6 ± 6.3 cm in the N/S group, 2.4 ± 6.0 cm in the F group, and - 1.6 ± 5.8 cm in the T group. The F group differed from the N/S group (P < 0.01). Intravenous administration of tenoxicam does not enhance the level of spinal analgesia produced by lidocaine.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalActa Anaesthesiologica Belgica
Volume48
Issue number4
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

tenoxicam
Lidocaine
Analgesia
Therapeutics
Spinal Anesthesia
Fentanyl
Intravenous Administration
Opioid Analgesics
Anti-Inflammatory Agents

Keywords

  • Analgesics
  • Anesthesia
  • Fentanyl
  • Lidocaine
  • Local anesthetics
  • Subarachnoid
  • Tenoxicam

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Tenoxicam does not enhance the spread of sensory block produced by intrathecal lidocaine. / Fassoulaki, A.; Sarantopoulos, Konstantinos D.; Zotou, M.

In: Acta Anaesthesiologica Belgica, Vol. 48, No. 4, 01.12.1997, p. 233-238.

Research output: Contribution to journalArticle

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abstract = "Systemic opioids enhance the spread of spinal analgesia. This study was designed to determine whether i.v. tenoxicam, a nonsteroidal anti- inflammatory drug (NSAID), affects the spread of sensory block produced by lidocaine. Sixty patients undergoing transurethral procedures were randomly assigned in a double blind design to receive i.v. either 3 ml normal saline (N/S group, n = 20), or 150 μg fentanyl (F group, n = 20), or 40 mg tenoxicam (T group, n = 20), 20 minutes after spinal anesthesia. The level of sensory loss was tested with pinprick sensation 20 minutes after subarachnoid block, but before i.v. treatment, and 5, 10, and 15 minutes after i.v. treatment. Five minutes after the i.v. treatment the change in the level of sensory block was -0.8 ± 3.1 cm in the N/S group, 4.0 ± 3.5 cm in the F group and 0.0 ± 3.9 cm in the T group. The changes in the height of sensory block among the three groups differed 5 minutes and 10 minutes (F = 10.627, df = 2.57, P < 0.001 and F = 4.219, df = 2,57, P < 0.05 respectively), but not 15 minutes after i.v. treatment. Individual comparisons showed a difference between the N/S and F groups (P < 0.01), and between the F and T groups (P < 0.01) 5 minutes after treatment, and between the N/S and F groups (P < 0.05) 10 minutes after treatment. The overall change in the level of sensory block 15 minutes after i.v. treatment was - 4.6 ± 6.3 cm in the N/S group, 2.4 ± 6.0 cm in the F group, and - 1.6 ± 5.8 cm in the T group. The F group differed from the N/S group (P < 0.01). Intravenous administration of tenoxicam does not enhance the level of spinal analgesia produced by lidocaine.",
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