Abstract
The Antibiotic Stewardship and Resistance Working Groups of the International Society for Chemotherapy propose ten key points for the appropriate use of antibiotics in hospital settings. (i) Get appropriate microbiological samples before antibiotic administration and carefully interpret the results: in the absence of clinical signs of infection, colonisation rarely requires antimicrobial treatment. (ii) Avoid the use of antibiotics to ‘treat’ fever: use them to treat infections, and investigate the root cause of fever prior to starting treatment. (iii) Start empirical antibiotic treatment after taking cultures, tailoring it to the site of infection, risk factors for multidrug-resistant bacteria, and the local microbiology and susceptibility patterns. (iv) Prescribe drugs at their optimal dosing and for an appropriate duration, adapted to each clinical situation and patient characteristics. (v) Use antibiotic combinations only where the current evidence suggests some benefit. (vi) When possible, avoid antibiotics with a higher likelihood of promoting drug resistance or hospital-acquired infections, or use them only as a last resort. (vii) Drain the infected foci quickly and remove all potentially or proven infected devices: control the infection source. (viii) Always try to de-escalate/streamline antibiotic treatment according to the clinical situation and the microbiological results. (ix) Stop unnecessarily prescribed antibiotics once the absence of infection is likely. And (x) Do not work alone: set up local teams with an infectious diseases specialist, clinical microbiologist, hospital pharmacist, infection control practitioner or hospital epidemiologist, and comply with hospital antibiotic policies and guidelines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-246 |
| Number of pages | 8 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2016 |
Fingerprint
Keywords
- Antimicrobial resistance
- Antimicrobial stewardship
- Combination therapy
- Prudent use of antibiotics
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases
Cite this
Ten key points for the appropriate use of antibiotics in hospitalised patients : a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy. / Levy Hara, Gabriel; Kanj, Souha S.; Pagani, Leonardo; Abbo, Lilian; Endimiani, Andrea; Wertheim, Heiman F L; Amábile-Cuevas, Carlos; Tattevin, Pierre; Mehtar, Shaheen; Lopes Cardoso, Fernando; Unal, Serhat; Gould, Ian.
In: International Journal of Antimicrobial Agents, Vol. 48, No. 3, 01.09.2016, p. 239-246.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Ten key points for the appropriate use of antibiotics in hospitalised patients
T2 - a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy
AU - Levy Hara, Gabriel
AU - Kanj, Souha S.
AU - Pagani, Leonardo
AU - Abbo, Lilian
AU - Endimiani, Andrea
AU - Wertheim, Heiman F L
AU - Amábile-Cuevas, Carlos
AU - Tattevin, Pierre
AU - Mehtar, Shaheen
AU - Lopes Cardoso, Fernando
AU - Unal, Serhat
AU - Gould, Ian
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The Antibiotic Stewardship and Resistance Working Groups of the International Society for Chemotherapy propose ten key points for the appropriate use of antibiotics in hospital settings. (i) Get appropriate microbiological samples before antibiotic administration and carefully interpret the results: in the absence of clinical signs of infection, colonisation rarely requires antimicrobial treatment. (ii) Avoid the use of antibiotics to ‘treat’ fever: use them to treat infections, and investigate the root cause of fever prior to starting treatment. (iii) Start empirical antibiotic treatment after taking cultures, tailoring it to the site of infection, risk factors for multidrug-resistant bacteria, and the local microbiology and susceptibility patterns. (iv) Prescribe drugs at their optimal dosing and for an appropriate duration, adapted to each clinical situation and patient characteristics. (v) Use antibiotic combinations only where the current evidence suggests some benefit. (vi) When possible, avoid antibiotics with a higher likelihood of promoting drug resistance or hospital-acquired infections, or use them only as a last resort. (vii) Drain the infected foci quickly and remove all potentially or proven infected devices: control the infection source. (viii) Always try to de-escalate/streamline antibiotic treatment according to the clinical situation and the microbiological results. (ix) Stop unnecessarily prescribed antibiotics once the absence of infection is likely. And (x) Do not work alone: set up local teams with an infectious diseases specialist, clinical microbiologist, hospital pharmacist, infection control practitioner or hospital epidemiologist, and comply with hospital antibiotic policies and guidelines.
AB - The Antibiotic Stewardship and Resistance Working Groups of the International Society for Chemotherapy propose ten key points for the appropriate use of antibiotics in hospital settings. (i) Get appropriate microbiological samples before antibiotic administration and carefully interpret the results: in the absence of clinical signs of infection, colonisation rarely requires antimicrobial treatment. (ii) Avoid the use of antibiotics to ‘treat’ fever: use them to treat infections, and investigate the root cause of fever prior to starting treatment. (iii) Start empirical antibiotic treatment after taking cultures, tailoring it to the site of infection, risk factors for multidrug-resistant bacteria, and the local microbiology and susceptibility patterns. (iv) Prescribe drugs at their optimal dosing and for an appropriate duration, adapted to each clinical situation and patient characteristics. (v) Use antibiotic combinations only where the current evidence suggests some benefit. (vi) When possible, avoid antibiotics with a higher likelihood of promoting drug resistance or hospital-acquired infections, or use them only as a last resort. (vii) Drain the infected foci quickly and remove all potentially or proven infected devices: control the infection source. (viii) Always try to de-escalate/streamline antibiotic treatment according to the clinical situation and the microbiological results. (ix) Stop unnecessarily prescribed antibiotics once the absence of infection is likely. And (x) Do not work alone: set up local teams with an infectious diseases specialist, clinical microbiologist, hospital pharmacist, infection control practitioner or hospital epidemiologist, and comply with hospital antibiotic policies and guidelines.
KW - Antimicrobial resistance
KW - Antimicrobial stewardship
KW - Combination therapy
KW - Prudent use of antibiotics
UR - http://www.scopus.com/inward/record.url?scp=84984791473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84984791473&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2016.06.015
DO - 10.1016/j.ijantimicag.2016.06.015
M3 - Review article
C2 - 27502752
AN - SCOPUS:84984791473
VL - 48
SP - 239
EP - 246
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 3
ER -