Temporal properties of inferior colliculus neurons to photonic stimulation in the cochlea

Xiaodong Tan, Hunter Young, Agnella Izzo Matic, Whitney Zirkle, Suhrud M Rajguru, Claus Peter Richter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Infrared neural stimulation (INS) may be beneficial in auditory prostheses because of its spatially selective activation of spiral ganglion neurons. However, the response properties of single auditory neurons to INS and the possible contributions of its optoacoustic effects are yet to be examined. In this study, the temporal properties of auditory neurons in the central nucleus of the inferior colliculus (ICC) of guinea pigs in response to INS were characterized. Spatial selectivity of INS was observed along the tonotopically organized ICC. Trains of laser pulses and trains of acoustic clicks were used to evoke single unit responses in ICC of normal hearing animals. In response to INS, ICC neurons showed lower limiting rates, longer latencies, and lower firing efficiencies. In deaf animals, ICC neurons could still be stimulated by INS while unresponsive to acoustic stimulation. The site and spatial selectivity of INS both likely shaped the temporal properties of ICC neurons.

Original languageEnglish (US)
Article numbere12491
JournalPhysiological Reports
Volume3
Issue number8
DOIs
StatePublished - 2015

Fingerprint

Optics and Photonics
Inferior Colliculi
Cochlea
Neurons
Spiral Ganglion
Acoustic Stimulation
Cochlear Implants
Acoustics
Hearing
Guinea Pigs
Lasers

Keywords

  • Infrared neural stimulation
  • Limiting rate
  • Single unit

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Temporal properties of inferior colliculus neurons to photonic stimulation in the cochlea. / Tan, Xiaodong; Young, Hunter; Matic, Agnella Izzo; Zirkle, Whitney; Rajguru, Suhrud M; Richter, Claus Peter.

In: Physiological Reports, Vol. 3, No. 8, e12491, 2015.

Research output: Contribution to journalArticle

Tan, Xiaodong ; Young, Hunter ; Matic, Agnella Izzo ; Zirkle, Whitney ; Rajguru, Suhrud M ; Richter, Claus Peter. / Temporal properties of inferior colliculus neurons to photonic stimulation in the cochlea. In: Physiological Reports. 2015 ; Vol. 3, No. 8.
@article{6f1ef25e868d45edac52d16b2714d1a0,
title = "Temporal properties of inferior colliculus neurons to photonic stimulation in the cochlea",
abstract = "Infrared neural stimulation (INS) may be beneficial in auditory prostheses because of its spatially selective activation of spiral ganglion neurons. However, the response properties of single auditory neurons to INS and the possible contributions of its optoacoustic effects are yet to be examined. In this study, the temporal properties of auditory neurons in the central nucleus of the inferior colliculus (ICC) of guinea pigs in response to INS were characterized. Spatial selectivity of INS was observed along the tonotopically organized ICC. Trains of laser pulses and trains of acoustic clicks were used to evoke single unit responses in ICC of normal hearing animals. In response to INS, ICC neurons showed lower limiting rates, longer latencies, and lower firing efficiencies. In deaf animals, ICC neurons could still be stimulated by INS while unresponsive to acoustic stimulation. The site and spatial selectivity of INS both likely shaped the temporal properties of ICC neurons.",
keywords = "Infrared neural stimulation, Limiting rate, Single unit",
author = "Xiaodong Tan and Hunter Young and Matic, {Agnella Izzo} and Whitney Zirkle and Rajguru, {Suhrud M} and Richter, {Claus Peter}",
year = "2015",
doi = "10.14814/phy2.12491",
language = "English (US)",
volume = "3",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Temporal properties of inferior colliculus neurons to photonic stimulation in the cochlea

AU - Tan, Xiaodong

AU - Young, Hunter

AU - Matic, Agnella Izzo

AU - Zirkle, Whitney

AU - Rajguru, Suhrud M

AU - Richter, Claus Peter

PY - 2015

Y1 - 2015

N2 - Infrared neural stimulation (INS) may be beneficial in auditory prostheses because of its spatially selective activation of spiral ganglion neurons. However, the response properties of single auditory neurons to INS and the possible contributions of its optoacoustic effects are yet to be examined. In this study, the temporal properties of auditory neurons in the central nucleus of the inferior colliculus (ICC) of guinea pigs in response to INS were characterized. Spatial selectivity of INS was observed along the tonotopically organized ICC. Trains of laser pulses and trains of acoustic clicks were used to evoke single unit responses in ICC of normal hearing animals. In response to INS, ICC neurons showed lower limiting rates, longer latencies, and lower firing efficiencies. In deaf animals, ICC neurons could still be stimulated by INS while unresponsive to acoustic stimulation. The site and spatial selectivity of INS both likely shaped the temporal properties of ICC neurons.

AB - Infrared neural stimulation (INS) may be beneficial in auditory prostheses because of its spatially selective activation of spiral ganglion neurons. However, the response properties of single auditory neurons to INS and the possible contributions of its optoacoustic effects are yet to be examined. In this study, the temporal properties of auditory neurons in the central nucleus of the inferior colliculus (ICC) of guinea pigs in response to INS were characterized. Spatial selectivity of INS was observed along the tonotopically organized ICC. Trains of laser pulses and trains of acoustic clicks were used to evoke single unit responses in ICC of normal hearing animals. In response to INS, ICC neurons showed lower limiting rates, longer latencies, and lower firing efficiencies. In deaf animals, ICC neurons could still be stimulated by INS while unresponsive to acoustic stimulation. The site and spatial selectivity of INS both likely shaped the temporal properties of ICC neurons.

KW - Infrared neural stimulation

KW - Limiting rate

KW - Single unit

UR - http://www.scopus.com/inward/record.url?scp=84973383952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973383952&partnerID=8YFLogxK

U2 - 10.14814/phy2.12491

DO - 10.14814/phy2.12491

M3 - Article

AN - SCOPUS:84973383952

VL - 3

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 8

M1 - e12491

ER -