Temporal network approach to unraveling collective neuron firings

Blazej Ruszczycki, Zhenyuan Zhao, Nicholas Johnson, Neil F Johnson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

As interest escalates in the area of temporal networks, the possibility arises that such tools might help unravel the complex dynamics of potentially correlated spatiotemporal events in complex systems. Here, we present such an analysis for a dataset comprising neuronal spike trains from retinal ganglion cells in a salamander. The neuron firing events are detected experimentally using a flat array of extracellular electrodes at micrometre scale separations, with spikes from the ganglion cell layer then being sorted into single-unit spike trains.We develop a temporal network analysis of this ensemble of spike trains that allows us to explore potential causality between firings. We compare our results to a randomized system in order to deduce a statistical Z-score and find examples of both event amplification and inhibition. Although the application to neuron firings is of direct interest for understanding brain function, the network approach that we present can in principle be applied to any set of timelines detailing the occurrence of events in particular regions, sectors or entities, including the search for causality between events in human activities such as crime.

Original languageEnglish (US)
Pages (from-to)74-84
Number of pages11
JournalJournal of Complex Networks
Volume2
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Dynamical networks
  • Mathematical and numerical analysis of networks
  • Networks and neuroscience

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Management Science and Operations Research
  • Applied Mathematics
  • Computational Mathematics
  • Control and Optimization

Fingerprint Dive into the research topics of 'Temporal network approach to unraveling collective neuron firings'. Together they form a unique fingerprint.

  • Cite this