Temporal lobectomy in early childhood

M. Duchowny, Bonnie Levin, P. Jayakar, T. Resnick, L. Alvarez, G. Morrison, P. Dean

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

Children with medically resistant temporal lobe seizures that persist into adolescence often experience psychosocial deterioration and medical morbidity. It is therefore especially important to evaluate the contribution of surgical therapy in preadolescent children. We describe our experience with temporal lobectomy in 16 children <12 years (mean age 7 years) who had intractable seizures of temporal lobe origin. Structural lesions were identified on neuroimaging studies in 11 patients. In all patients, the standard anterior temporal lobectomy was tailored according to the extent of the lesion and epileptogenic field. At follow-up, 11 children were seizure- free, three were 90% improved, one was 50% improved, and one was unchanged. Neuropathological abnormalities were identified in virtually all children. Prenatally acquired abnormalities of neurogenesis were the most common, whereas mesial temporal sclerosis was found in only two children. We conclude that tailored temporal lobectomy in the first decade of life is highly beneficial in carefully selected children with medically refractory seizures.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalEpilepsia
Volume33
Issue number2
StatePublished - Jan 1 1992

Fingerprint

Seizures
Temporal Lobe
Anterior Temporal Lobectomy
Neurogenesis
Sclerosis
Neuroimaging
Morbidity
Therapeutics

Keywords

  • Child
  • Epilepsy
  • Neurosurgery
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Duchowny, M., Levin, B., Jayakar, P., Resnick, T., Alvarez, L., Morrison, G., & Dean, P. (1992). Temporal lobectomy in early childhood. Epilepsia, 33(2), 298-303.

Temporal lobectomy in early childhood. / Duchowny, M.; Levin, Bonnie; Jayakar, P.; Resnick, T.; Alvarez, L.; Morrison, G.; Dean, P.

In: Epilepsia, Vol. 33, No. 2, 01.01.1992, p. 298-303.

Research output: Contribution to journalArticle

Duchowny, M, Levin, B, Jayakar, P, Resnick, T, Alvarez, L, Morrison, G & Dean, P 1992, 'Temporal lobectomy in early childhood', Epilepsia, vol. 33, no. 2, pp. 298-303.
Duchowny M, Levin B, Jayakar P, Resnick T, Alvarez L, Morrison G et al. Temporal lobectomy in early childhood. Epilepsia. 1992 Jan 1;33(2):298-303.
Duchowny, M. ; Levin, Bonnie ; Jayakar, P. ; Resnick, T. ; Alvarez, L. ; Morrison, G. ; Dean, P. / Temporal lobectomy in early childhood. In: Epilepsia. 1992 ; Vol. 33, No. 2. pp. 298-303.
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