Temporal lobectomy for seizures associated with unilateral schizencephaly

Howard J. Landy, R. Eugene Ramsay, Cosimo Ajmone-Marsan, Bonnie E. Levin, Jay Brown, Guillermo Pasarin, Robert M. Quencer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Schizencephaly is characterized by unilateral or bilateral cerebral clefts associated with neurologic deficits and epilepsy. Most commonly schizencephaly is attributed to abnormal neuronal migration, and these malformations are well visualized by current neuroimaging techniques. This report describes a patient with unilateral schizencephaly and poorly controlled complex partial seizures who was found to have a temporal lobe seizure focus; anterior temporal lobectomy produced nearly complete control of the seizures. Despite the extensive malformation, relatively restricted resection was of significant benefit. The principles of seizure focus localization and resection are applicable to the management of patients with schizencephaly.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalSurgical neurology
Issue number6
StatePublished - Jun 1992


  • Epilepsy
  • Neuronal migration
  • Schizencephaly

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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