Temporal lobe gangliogliomas associated with chronic epilepsy: Long-term surgical outcomes

David Wallace, Dmitry Ruban, Andres Kanner, Michael Smith, Lisa Pitelka, Jonathan Stein, Prasad S.S.V. Vannemreddy, Walt W. Whisler, Richard W. Byrne

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: To review the clinical features and surgical outcome in patients with temporal lobe gangliogliomas associated with intractable chronic epilepsy. Methods: The Rush University Surgical Epilepsy Database was queried to identify patients with chronic intractable epilepsy who underwent resection of temporal lobe gangliogliomas at Rush University Medical Center. Medical records were reviewed for age of seizure onset, delay to referral for surgery, seizure frequency and characteristics, pre-operative MRI results, extent of resection, pathological diagnosis, complications, length of follow-up, and seizure improvement. Results: Fifteen patients were identified. Average duration between seizure onset and surgery was 14.3 years. Complex partial seizures were the most common presenting symptom. Detailed operative data was available for 11 patients-of these, 90.9% underwent complete resection of the amygdala and either partial or complete resection of the hippocampus, in addition to lesionectomy. Average follow-up was 10.4 years (range 1.6-27.5 years), with 14 patients improving to Engel's class I and one patient to Engel's class III. There were no recurrences, and permanent complications were noted in one patient. Conclusions: Long-term follow-up of patients with temporal lobe gangliogliomas associated with chronic intractable epilepsy demonstrates excellent results in seizure improvement with surgery and increasingly low incidence of complications with improvements in microsurgical techniques.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalClinical Neurology and Neurosurgery
Issue number4
StatePublished - Apr 1 2013
Externally publishedYes


  • Chronic epilepsy
  • Ganglioglioma
  • Supratentorial neoplasm
  • Temporal lobe tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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