Abstract
The finite proliferative potential of normal human fibroblasts can be overcome, a process commonly called immortalization, by the introduction of the catalytic subunit of human telomerase. In contrast to malignant transformation, the pattern of gene expression remains largely unmodified in telomerase-induced immortalization. Here we show evidence that suggests that the maintenance of a "young" pattern of gene expression by telomerization is mediated, at least in part, by a novel function of human telomerase that involves regulation of DNA methyltransferase I gene expression.
Original language | English (US) |
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Pages (from-to) | 19904-19908 |
Number of pages | 5 |
Journal | Journal of Biological Chemistry |
Volume | 278 |
Issue number | 22 |
DOIs | |
State | Published - May 30 2003 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology