Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I

Juan I. Young, John M. Sedivy, James R. Smith

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The finite proliferative potential of normal human fibroblasts can be overcome, a process commonly called immortalization, by the introduction of the catalytic subunit of human telomerase. In contrast to malignant transformation, the pattern of gene expression remains largely unmodified in telomerase-induced immortalization. Here we show evidence that suggests that the maintenance of a "young" pattern of gene expression by telomerization is mediated, at least in part, by a novel function of human telomerase that involves regulation of DNA methyltransferase I gene expression.

Original languageEnglish (US)
Pages (from-to)19904-19908
Number of pages5
JournalJournal of Biological Chemistry
Volume278
Issue number22
DOIs
StatePublished - May 30 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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