Telangiectatic Osteosarcoma: Radiologic-Pathologic Comparison

Mark D. Murphey, Suphanee Wan Jaovisidha, H. Thomas Temple, Francis H. Gannon, James S. Jelinek, Martin M. Malawer

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

PURPOSE: To describe the imaging characteristics of a large series of telangiectatic osteosarcomas with pathologic findings for comparison. MATERIALS AND METHODS: The authors retrospectively reviewed 40 pathologically confirmed telangiectatic osteosarcomas. Patient demographics and images from radiography (n = 36), bone scintigraphy (n = 17), angiography (n = 4), computed tomography (CT) (n = 25), and magnetic resonance (MR) imaging (n = 27) were evaluated by three authors in consensus for lesion location, size, and intrinsic characteristics. There were 27 men (68%) and 13 women (32%) in the study, with an age range of 4-83 years (mean age, 24 years). RESULTS: Lesions frequently affected the femur, tibia, and humerus. Radiographs showed geographic bone lysis, a wide zone of transition, and matrix mineralization. CT demonstrated low attenuation, MR demonstrated high signal intensity on T2-weighted images, and both demonstrated hemorrhage, which simulated the appearance of aneurysmal bone cyst. Viable sarcomatous tissue surrounding hemorrhagic and/or necrotic regions was best seen at contrast material-enhanced CT and MR imaging, with thick peripheral, septal, and nodular enhancement in all cases. Subtle matrix mineralization in this viable tissue was best seen at CT. An associated soft-tissue mass was also seen in 19 of 25 cases (76%) at CT and in 24 of 27 cases (89%) at MR imaging. CONCLUSION: CT and MR imaging findings of telangiectatic osteosarcoma often include thick nodular tissue (and matrix mineralization at CT) in a largely hemorrhagic and/or necrotic osseous lesion with an associated soft-tissue mass, which allows distinction from aneurysmal bone cyst.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalRadiology
Volume229
Issue number2
DOIs
StatePublished - Nov 1 2003

Keywords

  • Bone neoplasms, CT
  • Bone neoplasms, MR
  • Osteosarcoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Murphey, M. D., Wan Jaovisidha, S., Temple, H. T., Gannon, F. H., Jelinek, J. S., & Malawer, M. M. (2003). Telangiectatic Osteosarcoma: Radiologic-Pathologic Comparison. Radiology, 229(2), 545-553. https://doi.org/10.1148/radiol.2292021130