Abstract
PURPOSE. To use optical coherence tomography (OCT) to evaluate the effect of punctal occlusion on tear meniscus volume in dry eye patients. METHODS. Occlusion of both upper and lower puncta with collagen plugs was performed on one eye each in 20 dry eye patients and 20 normal subjects. The upper and lower tear menisci were imaged simultaneously by real-time OCT before punctal occlusion and on days 1, 4, 7, and 10 afterward. The heights, cross-sectional areas, and volumes of the menisci were obtained. Schirmer I test with anesthesia and tear break-up time (TBUT) testing were also performed. RESULTS. At baseline, both upper and lower tear meniscus heights and volumes in dry eye patients were lower than those in control subjects (P < 0.05). The volume of the lower tear meniscus was 0.28 ± 0.09 μL in dry eye patients and 0.55 ± 0.22 μL in control subjects at baseline (P < 0.05). After punctal occlusion, the Schirmer I test scores of dry eye patients did not change (P > 0.05), but the heights and volumes of the upper and lower tear menisci increased (P < 0.05). In control subjects, Schirmer I test scores decreased (P < 0.05), but the heights and volumes of the upper and lower tear menisci did not change (P > 0.05). CONCLUSIONS. Punctal occlusion induced increases in the upper and lower tear meniscus volumes in dry eye patients. The absence of change in the tear menisci of control eyes may indicate the presence of an autoregulatory mechanism in the tear system that maintains a balance in the tear volume.
| Original language | English |
|---|---|
| Pages (from-to) | 1965-1969 |
| Number of pages | 5 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 51 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
- Medicine(all)
Cite this
Tear meniscus volume in dry eye after punctal occlusion. / Chen, Feng; Shen, Meixiao; Chen, Wei; Wang, Jianhua; Li, Ming; Yuan, Yimin; Lu, Fan.
In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 4, 01.04.2010, p. 1965-1969.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Tear meniscus volume in dry eye after punctal occlusion
AU - Chen, Feng
AU - Shen, Meixiao
AU - Chen, Wei
AU - Wang, Jianhua
AU - Li, Ming
AU - Yuan, Yimin
AU - Lu, Fan
PY - 2010/4/1
Y1 - 2010/4/1
N2 - PURPOSE. To use optical coherence tomography (OCT) to evaluate the effect of punctal occlusion on tear meniscus volume in dry eye patients. METHODS. Occlusion of both upper and lower puncta with collagen plugs was performed on one eye each in 20 dry eye patients and 20 normal subjects. The upper and lower tear menisci were imaged simultaneously by real-time OCT before punctal occlusion and on days 1, 4, 7, and 10 afterward. The heights, cross-sectional areas, and volumes of the menisci were obtained. Schirmer I test with anesthesia and tear break-up time (TBUT) testing were also performed. RESULTS. At baseline, both upper and lower tear meniscus heights and volumes in dry eye patients were lower than those in control subjects (P < 0.05). The volume of the lower tear meniscus was 0.28 ± 0.09 μL in dry eye patients and 0.55 ± 0.22 μL in control subjects at baseline (P < 0.05). After punctal occlusion, the Schirmer I test scores of dry eye patients did not change (P > 0.05), but the heights and volumes of the upper and lower tear menisci increased (P < 0.05). In control subjects, Schirmer I test scores decreased (P < 0.05), but the heights and volumes of the upper and lower tear menisci did not change (P > 0.05). CONCLUSIONS. Punctal occlusion induced increases in the upper and lower tear meniscus volumes in dry eye patients. The absence of change in the tear menisci of control eyes may indicate the presence of an autoregulatory mechanism in the tear system that maintains a balance in the tear volume.
AB - PURPOSE. To use optical coherence tomography (OCT) to evaluate the effect of punctal occlusion on tear meniscus volume in dry eye patients. METHODS. Occlusion of both upper and lower puncta with collagen plugs was performed on one eye each in 20 dry eye patients and 20 normal subjects. The upper and lower tear menisci were imaged simultaneously by real-time OCT before punctal occlusion and on days 1, 4, 7, and 10 afterward. The heights, cross-sectional areas, and volumes of the menisci were obtained. Schirmer I test with anesthesia and tear break-up time (TBUT) testing were also performed. RESULTS. At baseline, both upper and lower tear meniscus heights and volumes in dry eye patients were lower than those in control subjects (P < 0.05). The volume of the lower tear meniscus was 0.28 ± 0.09 μL in dry eye patients and 0.55 ± 0.22 μL in control subjects at baseline (P < 0.05). After punctal occlusion, the Schirmer I test scores of dry eye patients did not change (P > 0.05), but the heights and volumes of the upper and lower tear menisci increased (P < 0.05). In control subjects, Schirmer I test scores decreased (P < 0.05), but the heights and volumes of the upper and lower tear menisci did not change (P > 0.05). CONCLUSIONS. Punctal occlusion induced increases in the upper and lower tear meniscus volumes in dry eye patients. The absence of change in the tear menisci of control eyes may indicate the presence of an autoregulatory mechanism in the tear system that maintains a balance in the tear volume.
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U2 - 10.1167/iovs.09-4349
DO - 10.1167/iovs.09-4349
M3 - Article
C2 - 19933200
AN - SCOPUS:77951232633
VL - 51
SP - 1965
EP - 1969
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 4
ER -