Abstract
PURPOSE. To investigate the relationship between tear meniscus volumes and ocular discomfort during daily soft contact lens wear in symptomatic and asymptomatic wearers. METHODS. Three groups of subjects (n = 20 each) were enrolled. Group 1: symptomatic lens wearers; group 2: asymptomatic lens wearers; group 3: asymptomatic non-lens wearers. Lenses were worn on both eyes and imaged at 2, 4, 6, 8, and 10 hours by optical coherence tomography (OCT). Afterward, a re-wetting drop was instilled onto a randomly selected eye of each subject and re-imaged immediately and at 5, 10, 20, and 30 minutes. Tear meniscus volumes were calculated based on meniscus areas and eyelid lengths. Ocular comfort was also ranked at each time point. RESULTS. Upper and lower meniscus volumes in group 1 were the lowest among the three groups at each time point (P < 0.05). For each group, meniscus volumes decreased gradually during the 10-hour study period (P < 0.05). Among the individuals in each group, the comfort ratings were linearly correlated with the tear meniscus volumes during the 10 hours of lens wear (r = 0.21- 0.47, all P < 0.05).Tear volume increased after re-wetting, but lasted only 10 - 20 minutes. Ocular comfort in groups 1 and 2 increased after instillation, but lasted only 10 and 20 minutes, respectively. Ocular comfort in group 3 did not improve. CONCLUSIONS. Tear volume decreased gradually during lens wear and contributed to the ocular comfort in both symptomatic and asymptomatic wearers. The efficacy of re-wetting was brief.
| Original language | English |
|---|---|
| Pages (from-to) | 2175-2180 |
| Number of pages | 6 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 1 2011 |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Tear menisci and ocular discomfort during daily contact lens wear in symptomatic wearers. / Chen, Qi; Wang, Jianhua; Shen, Meixiao; Cui, Lele; Cai, Chunyan; Li, Ming; Li, Kangjun; Lu, Fan.
In: Investigative Ophthalmology and Visual Science, Vol. 52, No. 5, 01.04.2011, p. 2175-2180.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Tear menisci and ocular discomfort during daily contact lens wear in symptomatic wearers
AU - Chen, Qi
AU - Wang, Jianhua
AU - Shen, Meixiao
AU - Cui, Lele
AU - Cai, Chunyan
AU - Li, Ming
AU - Li, Kangjun
AU - Lu, Fan
PY - 2011/4/1
Y1 - 2011/4/1
N2 - PURPOSE. To investigate the relationship between tear meniscus volumes and ocular discomfort during daily soft contact lens wear in symptomatic and asymptomatic wearers. METHODS. Three groups of subjects (n = 20 each) were enrolled. Group 1: symptomatic lens wearers; group 2: asymptomatic lens wearers; group 3: asymptomatic non-lens wearers. Lenses were worn on both eyes and imaged at 2, 4, 6, 8, and 10 hours by optical coherence tomography (OCT). Afterward, a re-wetting drop was instilled onto a randomly selected eye of each subject and re-imaged immediately and at 5, 10, 20, and 30 minutes. Tear meniscus volumes were calculated based on meniscus areas and eyelid lengths. Ocular comfort was also ranked at each time point. RESULTS. Upper and lower meniscus volumes in group 1 were the lowest among the three groups at each time point (P < 0.05). For each group, meniscus volumes decreased gradually during the 10-hour study period (P < 0.05). Among the individuals in each group, the comfort ratings were linearly correlated with the tear meniscus volumes during the 10 hours of lens wear (r = 0.21- 0.47, all P < 0.05).Tear volume increased after re-wetting, but lasted only 10 - 20 minutes. Ocular comfort in groups 1 and 2 increased after instillation, but lasted only 10 and 20 minutes, respectively. Ocular comfort in group 3 did not improve. CONCLUSIONS. Tear volume decreased gradually during lens wear and contributed to the ocular comfort in both symptomatic and asymptomatic wearers. The efficacy of re-wetting was brief.
AB - PURPOSE. To investigate the relationship between tear meniscus volumes and ocular discomfort during daily soft contact lens wear in symptomatic and asymptomatic wearers. METHODS. Three groups of subjects (n = 20 each) were enrolled. Group 1: symptomatic lens wearers; group 2: asymptomatic lens wearers; group 3: asymptomatic non-lens wearers. Lenses were worn on both eyes and imaged at 2, 4, 6, 8, and 10 hours by optical coherence tomography (OCT). Afterward, a re-wetting drop was instilled onto a randomly selected eye of each subject and re-imaged immediately and at 5, 10, 20, and 30 minutes. Tear meniscus volumes were calculated based on meniscus areas and eyelid lengths. Ocular comfort was also ranked at each time point. RESULTS. Upper and lower meniscus volumes in group 1 were the lowest among the three groups at each time point (P < 0.05). For each group, meniscus volumes decreased gradually during the 10-hour study period (P < 0.05). Among the individuals in each group, the comfort ratings were linearly correlated with the tear meniscus volumes during the 10 hours of lens wear (r = 0.21- 0.47, all P < 0.05).Tear volume increased after re-wetting, but lasted only 10 - 20 minutes. Ocular comfort in groups 1 and 2 increased after instillation, but lasted only 10 and 20 minutes, respectively. Ocular comfort in group 3 did not improve. CONCLUSIONS. Tear volume decreased gradually during lens wear and contributed to the ocular comfort in both symptomatic and asymptomatic wearers. The efficacy of re-wetting was brief.
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UR - http://www.scopus.com/inward/citedby.url?scp=79956043328&partnerID=8YFLogxK
U2 - 10.1167/iovs.10-5780
DO - 10.1167/iovs.10-5780
M3 - Article
C2 - 21051728
AN - SCOPUS:79956043328
VL - 52
SP - 2175
EP - 2180
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 5
ER -