tc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients

Compared with CT-a prospective study

Kester Nedd, George N Sfakianakis, William Ganz, Bradford Uricchio, Dee Vernberg, Phillip Villanueva, A. M. Jabir, Jerry Bartlett, Julie Keena

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Single photon emission computed tomography (SPECT) with Technetium-99m hexamethyl propylenamine oxime (Tc-99m-HMPAO) was used in 20 patients with mild to moderate traumatic brain injury (TBI) to evaluate the effects of brain trauma on regional cerebral blood flow (rCBF). SPECT scan was compared with CT scan in 16 patients. SPECT showed intraparenchymal differences in rCBF more often than lesions diagnosed with CT scans (87 -5% vs. 37-5% In five of six patients with lesions in both modalities, the area of involvement was relatively larger on SPECT scans than on CT scans. Contrecoup changes were seen in five patients on SPECT alone, two patients with CT alone and one patient had contrecoup lesions on CT and SPECT. Of the eight patients (50% with skull fractures, seven (43-7% had rCBF findings on SPECT scan and five (31.3% demonstrated decrease in rCBF in brain underlying the fracture. All these patients with fractures had normal brain on CT scans. Conversely, extra-axial lesions and fractures evident on CT did not visualize on SPECT, but SPECT demonstrated associated changes in rCBF. Although there is still lack of clinical and pathological correlation, SPECT appears to be a promising method for a more sensitive evaluation of axial lesions in patients with mild to moderate TBI.

Original languageEnglish
Pages (from-to)469-479
Number of pages11
JournalBrain Injury
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1993

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Single-Photon Emission-Computed Tomography
Cerebrovascular Circulation
Prospective Studies
Regional Blood Flow
Brain
Skull Fractures
Traumatic Brain Injury
Oximes
Technetium

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Nedd, K., Sfakianakis, G. N., Ganz, W., Uricchio, B., Vernberg, D., Villanueva, P., ... Keena, J. (1993). tc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients: Compared with CT-a prospective study. Brain Injury, 7(6), 469-479. https://doi.org/10.3109/02699059309008174

tc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients : Compared with CT-a prospective study. / Nedd, Kester; Sfakianakis, George N; Ganz, William; Uricchio, Bradford; Vernberg, Dee; Villanueva, Phillip; Jabir, A. M.; Bartlett, Jerry; Keena, Julie.

In: Brain Injury, Vol. 7, No. 6, 01.01.1993, p. 469-479.

Research output: Contribution to journalArticle

Nedd, K, Sfakianakis, GN, Ganz, W, Uricchio, B, Vernberg, D, Villanueva, P, Jabir, AM, Bartlett, J & Keena, J 1993, 'tc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients: Compared with CT-a prospective study', Brain Injury, vol. 7, no. 6, pp. 469-479. https://doi.org/10.3109/02699059309008174
Nedd, Kester ; Sfakianakis, George N ; Ganz, William ; Uricchio, Bradford ; Vernberg, Dee ; Villanueva, Phillip ; Jabir, A. M. ; Bartlett, Jerry ; Keena, Julie. / tc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients : Compared with CT-a prospective study. In: Brain Injury. 1993 ; Vol. 7, No. 6. pp. 469-479.
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